Cntn2 contactin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cntn2provided by RGD
Official Full Name: contactin 2provided by RGD
Primary source: RGD:3821
See related: EnsemblRapid:ENSRNOG00000009033 AllianceGenome:RGD:3821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tax; TAG1; TAG-1; TAG-564
Summary: Predicted to enable carbohydrate binding activity; cell-cell adhesion mediator activity; and protein self-association. Involved in axonogenesis and cell-matrix adhesion. Located in plasma membrane and synapse. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 5. Orthologous to human CNTN2 (contactin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 99.6), Lung (RPKM 11.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (46497269..46528112, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (43942868..43975973, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (49280913..49314061, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-34a regulates Schwann cell proliferation and migration by targeting CNTN2.
Title: MiR-34a regulates Schwann cell proliferation and migration by targeting CNTN2.
the biological effects of miR-3075 on Schwann cell phenotype might by through the negative regulation of contactin 2
Title: miR-3075 Inhibited the Migration of Schwann Cells by Targeting Cntn2.
RT-PCR and Western blotting methods showed that 20 muM Abeta25-35 could increase the expression levels of TAG1, APP, AICD and p53 (P<0.01) while they decreased in BMSCs + Abeta25-35 group
Title: Protective effect of bone marrow mesenchymal stem cells on PC12 cells apoptosis mediated by TAG1.
Adoptive transfer of TAG-1-specific T cells induced encephalitis characterized by a preferential inflammation of gray matter of the spinal cord and cortex, identifying TAG-1 as an autoantigen targeted by T cells
Title: Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals.
Expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers.
Title: The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers.
Tag-1 is expressed in migrating embryonic neurons that will form the lateral reticular and basilar pontine nuclei.
Title: Nr-CAM and TAG-1 are expressed in distinct populations of developing precerebellar and cerebellar neurons.

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General gene information

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Markers

AW528446 (e-PCR)
- UniSTS:246606

RH142422 (e-PCR)
- UniSTS:231669

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion mediator activity	IEA Inferred from Electronic Annotation more info
enables cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of G protein-coupled adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axonal fasciculation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonal fasciculation	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex GABAergic interneuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration	ISO Inferred from Sequence Orthology more info
involved_in clustering of voltage-gated potassium channels	IEA Inferred from Electronic Annotation more info
involved_in clustering of voltage-gated potassium channels	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to juxtaparanode region of axon	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenosine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of adenosine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane organization	IEA Inferred from Electronic Annotation more info
involved_in presynaptic membrane organization	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein processing	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in reduction of food intake in response to dietary excess	IEA Inferred from Electronic Annotation more info
involved_in reduction of food intake in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon diameter	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of axon diameter	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon initial segment	IEA Inferred from Electronic Annotation more info
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in juxtaparanode region of axon	IEA Inferred from Electronic Annotation more info
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	IEA Inferred from Electronic Annotation more info
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: contactin-2

Names: TAX-1; axonal glycoprotein TAG-1; axonin-1; contactin 2 (axonal); transient axonal glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012884.2 → NP_037016.2 contactin-2 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P22063

UniProtKB/TrEMBL

A6IC54, G3V758

Related

ENSRNOP00000012190.2, ENSRNOT00000012190.5

Conserved Domains (6) summary

cd05728
Location:330 → 414

Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains

cd00063
Location:817 → 909

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:509 → 515

Ig; Ig strand A [structural motif]

cd04969
Location:419 → 507

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cd05727
Location:141 → 230

Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains

cl11960
Location:509 → 605

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

46497269..46528112 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090383.2 → XP_038946311.1 contactin-2 isoform X2

UniProtKB/Swiss-Prot

P22063

Conserved Domains (6) summary

cd05728
Location:330 → 414

Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains

cd00063
Location:816 → 908

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:509 → 515

Ig; Ig strand A [structural motif]

cd04969
Location:419 → 507

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cd05727
Location:141 → 230

Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains

cl11960
Location:509 → 604

Ig; Immunoglobulin domain
XM_006249746.5 → XP_006249808.1 contactin-2 isoform X1

See identical proteins and their annotated locations for XP_006249808.1

UniProtKB/Swiss-Prot

P22063

UniProtKB/TrEMBL

A6IC54, G3V758

Conserved Domains (6) summary

cd05728
Location:330 → 414

Ig4_Contactin-2-like; Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains

cd00063
Location:817 → 909

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:509 → 515

Ig; Ig strand A [structural motif]

cd04969
Location:419 → 507

Ig5_Contactin; Fifth immunoglobulin (Ig) domain of contactin

cd05727
Location:141 → 230

Ig2_Contactin-2-like; Second Ig domain of the neural cell adhesion molecule contactin-2, and similar domains

cl11960
Location:509 → 605

Ig; Immunoglobulin domain