Cdk12 cyclin-dependent kinase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdk12provided by RGD
Official Full Name: cyclin-dependent kinase 12provided by RGD
Primary source: RGD:621111
See related: EnsemblRapid:ENSRNOG00000006000 AllianceGenome:RGD:621111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hgn; Crk7; Pksc; Crkrs
Summary: Enables cyclin binding activity. Involved in RNA splicing and regulation of RNA splicing. Located in nuclear speck. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 211.9), Spleen (RPKM 175.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (83697174..83793676)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (83201177..83256906)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (86157186..86210657)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing.
Title: Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.

Submit: New GeneRIF Correction

General gene information

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Markers

D10Got125 (e-PCR)
- UniSTS:111957

AI646528 (e-PCR)
- UniSTS:180316

RH143339 (e-PCR)
- UniSTS:232586

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of RNA splicing	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of cyclin K-CDK12 complex	IEA Inferred from Electronic Annotation more info
part_of cyclin K-CDK12 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase 12

Names: CDC2-related kinase 7; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; hippyragranin; protein kinase for splicing component

NP_001029039.1

EC 2.7.11.22

EC 2.7.11.23

NP_620271.1

EC 2.7.11.22

EC 2.7.11.23

XP_006247312.1

EC 2.7.11.22

EC 2.7.11.23

XP_006247313.1

EC 2.7.11.22

EC 2.7.11.23

XP_038941089.1

EC 2.7.11.22

EC 2.7.11.23

XP_063124451.1

EC 2.7.11.22

EC 2.7.11.23

XP_063124452.1

EC 2.7.11.22

EC 2.7.11.23

XP_063124453.1

EC 2.7.11.22

EC 2.7.11.23

XP_063124454.1

EC 2.7.11.22

EC 2.7.11.23

XP_063124455.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033867.2 → NP_001029039.1 cyclin-dependent kinase 12 isoform 1

See identical proteins and their annotated locations for NP_001029039.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q3MJK5, Q8R458

Related

ENSRNOP00000105670.1, ENSRNOT00000122409.1

Conserved Domains (2) summary

smart00220
Location:723 → 1016

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
NM_138916.2 → NP_620271.1 cyclin-dependent kinase 12 isoform 2

See identical proteins and their annotated locations for NP_620271.1

Status: VALIDATED

Source sequence(s)

AY072294, BE117540

UniProtKB/TrEMBL

A6HIQ9

Conserved Domains (2) summary

smart00220
Location:723 → 1016

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

83697174..83793676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268383.1 → XP_063124453.1 cyclin-dependent kinase 12 isoform X3

UniProtKB/TrEMBL

A0A0G2K5U7
XM_063268381.1 → XP_063124451.1 cyclin-dependent kinase 12 isoform X3

UniProtKB/TrEMBL

A0A0G2K5U7
XM_063268382.1 → XP_063124452.1 cyclin-dependent kinase 12 isoform X3

UniProtKB/TrEMBL

A0A0G2K5U7
XM_063268384.1 → XP_063124454.1 cyclin-dependent kinase 12 isoform X4
XM_063268385.1 → XP_063124455.1 cyclin-dependent kinase 12 isoform X6

UniProtKB/TrEMBL

A0A8I6AHH6

Related

ENSRNOP00000087177.2, ENSRNOT00000114817.2
XM_006247251.5 → XP_006247313.1 cyclin-dependent kinase 12 isoform X2

Conserved Domains (2) summary

smart00220
Location:723 → 1016

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_006247250.5 → XP_006247312.1 cyclin-dependent kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8L2Q358

Related

ENSRNOP00000008256.3, ENSRNOT00000008256.6

Conserved Domains (2) summary

smart00220
Location:722 → 1015

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:714 → 1015

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_039085161.2 → XP_038941089.1 cyclin-dependent kinase 12 isoform X5

UniProtKB/TrEMBL

A0A8I6A3V7

Related

ENSRNOP00000092388.2, ENSRNOT00000105342.2

Conserved Domains (1) summary

cd07864
Location:715 → 1016

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12