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    Rab3ip RAB3A interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29885, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rab3ipprovided by RGD
    Official Full Name
    RAB3A interacting proteinprovided by RGD
    Primary source
    RGD:620650
    See related
    Ensembl:ENSRNOG00000005362 AllianceGenome:RGD:620650
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RABIN3
    Summary
    Enables GTPase binding activity and guanyl-nucleotide exchange factor activity. Involved in negative regulation of filopodium assembly. Located in cytosol; perinuclear region of cytoplasm; and proximal dendrite. Colocalizes with Golgi apparatus. Orthologous to human RAB3IP (RAB3A interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 204.7), Thymus (RPKM 120.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (54417418..54461253, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (52531461..52575295, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (59927486..59971518, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene myelin regulatory factor-like Neighboring gene H3.3 histone A, pseudogene 5 Neighboring gene bestrophin 3 Neighboring gene uncharacterized LOC134479874 Neighboring gene uncharacterized LOC120093598

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. Hattula K, et al. Mol Biol Cell, 2002 Sep. PMID 12221131, Free PMC Article
    2. Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11. Vetter M, et al. Nat Struct Mol Biol, 2015 Sep. PMID 26258637
    3. RabGEFs are a major determinant for specific Rab membrane targeting. Blümer J, et al. J Cell Biol, 2013 Feb 4. PMID 23382462, Free PMC Article
    4. NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. Chiba S, et al. EMBO J, 2013 Mar 20. PMID 23435566, Free PMC Article
    5. Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A. Brondyk WH, et al. Mol Cell Biol, 1995 Mar. PMID 7532276, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi to plasma membrane transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in proximal dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rab-3A-interacting protein
    Names
    SSX2-interacting protein
    rab3A-interacting protein
    rabin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017313.3 → NP_059009.2  rab-3A-interacting protein

      See identical proteins and their annotated locations for NP_059009.2

      Status: PROVISIONAL

      Source sequence(s)
      BC127500
      UniProtKB/Swiss-Prot
      A1L127, Q62739
      UniProtKB/TrEMBL
      A0A0G2K1B4
      Related
      ENSRNOP00000007258.4, ENSRNOT00000007258.6
      Conserved Domains (3) summary
      COG4372
      Location:98 → 240
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam06428
      Location:173 → 241
      Sec2p; GDP/GTP exchange factor Sec2p
      cd21068
      Location:266 → 458
      Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      54417418..54461253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241357.5 → XP_006241419.1  rab-3A-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006241419.1

      UniProtKB/Swiss-Prot
      A1L127, Q62739
      UniProtKB/TrEMBL
      A0A0G2K1B4
      Conserved Domains (3) summary
      COG4372
      Location:98 → 240
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam06428
      Location:173 → 241
      Sec2p; GDP/GTP exchange factor Sec2p
      cd21068
      Location:266 → 458
      Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

    2. XM_006241360.4 → XP_006241422.1  rab-3A-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_006241422.1

      UniProtKB/Swiss-Prot
      A1L127, Q62739
      UniProtKB/TrEMBL
      A0A0G2K1B4
      Conserved Domains (3) summary
      COG4372
      Location:98 → 240
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      pfam06428
      Location:173 → 241
      Sec2p; GDP/GTP exchange factor Sec2p
      cd21068
      Location:266 → 458
      Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

    3. XM_039078619.1 → XP_038934547.1  rab-3A-interacting protein isoform X5

      UniProtKB/TrEMBL
      A6IGQ0
      Conserved Domains (1) summary
      cd21068
      Location:60 → 252
      Rab11BD_RAB3IP; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP)

    4. XM_063263145.1 → XP_063119215.1  rab-3A-interacting protein isoform X5

    5. XM_063263144.1 → XP_063119214.1  rab-3A-interacting protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZML7

    6. XM_063263143.1 → XP_063119213.1  rab-3A-interacting protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AR50

    7. XM_063263142.1 → XP_063119212.1  rab-3A-interacting protein isoform X1

      UniProtKB/Swiss-Prot
      A1L127, Q62739

    8. XM_008765383.4 → XP_008763605.1  rab-3A-interacting protein isoform X4

      UniProtKB/TrEMBL
      A6IGQ0
      Conserved Domains (1) summary
      pfam06428
      Location:22 → 103
      Sec2p; GDP/GTP exchange factor Sec2p

    9. XM_039078620.2 → XP_038934548.1  rab-3A-interacting protein isoform X6

      Conserved Domains (1) summary
      cl41767
      Location:1 → 182
      Rab11BD_RAB3IP_like; Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62739.2 GenPept UniProtKB/Swiss-Prot:Q62739

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