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    Asns asparagine synthetase (glutamine-hydrolyzing) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25612, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Asnsprovided by RGD
    Official Full Name
    asparagine synthetase (glutamine-hydrolyzing)provided by RGD
    Primary source
    RGD:2162
    See related
    Ensembl:ENSRNOG00000007546 AllianceGenome:RGD:2162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and response to follicle-stimulating hormone. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 212.2), Testes (RPKM 153.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (36752061..36769970, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (35784995..35803474, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (33742876..33761106, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tachykinin, precursor 1 Neighboring gene Set nuclear proto-oncogene, pseudogene 6 Neighboring gene uncharacterized LOC134486668 Neighboring gene tRNA (guanine-N(7)-)-methyltransferase-like Neighboring gene RNA polymerase I and III subunit D, pseudogene 1 Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional responses in thyroid tissues from rats treated with a tumorigenic and a non-tumorigenic triazole conazole fungicide. Hester SD, et al. Toxicol Appl Pharmacol, 2008 Mar 15. PMID 18164361
    2. Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. Hutson RG, et al. Am J Physiol, 1997 May. PMID 9176161
    3. Induction of asparagine synthetase by follicle-stimulating hormone in primary cultures of rat Sertoli cells. Hongo S, et al. Arch Biochem Biophys, 1994 Sep. PMID 7915898
    4. Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Hutson RG, et al. Biochem J, 1994 Dec 15. PMID 7818476, Free PMC Article
    5. Some molecular properties of asparagine synthetase from rat liver. Hongo S, et al. Biochim Biophys Acta, 1983 Feb 15. PMID 6132621

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93148

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asparagine synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in asparagine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within asparagine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to aldosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to amino acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to follicle-stimulating hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    asparagine synthetase [glutamine-hydrolyzing]
    Names
    glutamine-dependent asparagine synthetase
    NP_037211.2
    XP_006236151.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013079.2 → NP_037211.2  asparagine synthetase [glutamine-hydrolyzing]

      See identical proteins and their annotated locations for NP_037211.2

      Status: PROVISIONAL

      Source sequence(s)
      BC081719
      UniProtKB/Swiss-Prot
      P49088, Q66HR8
      UniProtKB/TrEMBL
      A6IDW2, A6IDW3
      Conserved Domains (1) summary
      PRK09431
      Location:1 → 560
      asnB; asparagine synthetase B; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      36752061..36769970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236089.5 → XP_006236151.1  asparagine synthetase [glutamine-hydrolyzing] isoform X1

      See identical proteins and their annotated locations for XP_006236151.1

      UniProtKB/Swiss-Prot
      P49088, Q66HR8
      UniProtKB/TrEMBL
      A6IDW2, A6IDW3
      Related
      ENSRNOP00000010079.3
      Conserved Domains (1) summary
      PRK09431
      Location:1 → 560
      asnB; asparagine synthetase B; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49088.3 GenPept UniProtKB/Swiss-Prot:P49088

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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