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    Aplp2 amyloid beta precursor like protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64312, updated on 28-Oct-2024

    Summary

    Official Symbol
    Aplp2provided by RGD
    Official Full Name
    amyloid beta precursor like protein 2provided by RGD
    Primary source
    RGD:2128
    See related
    EnsemblRapid:ENSRNOG00000047179 AllianceGenome:RGD:2128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Apph; CDEBP; APLP-2; WALPLP2
    Summary
    Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to act upstream of or within several processes, including brain development; regulation of epidermal growth factor-activated receptor activity; and suckling behavior. Predicted to be located in nucleus. Predicted to be active in spine apparatus. Used to study Alzheimer's disease. Biomarker of neurodegenerative disease. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 1040.3), Lung (RPKM 878.1) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Aplp2 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (37857407..37920487, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (29599230..29662311, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (32298526..32328821, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene uncharacterized LOC134480153 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spine apparatus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    amyloid beta precursor like protein 2
    Names
    Amyloid protein precursor-like protein 2
    CDEI box-binding protein
    amyloid beta (A4) precursor-like protein 2
    amyloid beta (A4) precursor-like protein 2-like
    amyloid protein homolog
    amyloid-like protein 2
    sperm membrane protein (YWK-II)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012906.1NP_037038.1  amyloid beta precursor like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_037038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BP497339, CA340752, CB700594, CB795867, FM029818, FM030557, FM039816, FM041002, FM044356, FM104554, FM112636
      UniProtKB/Swiss-Prot
      P15943
      UniProtKB/TrEMBL
      A6JYG2, M0RDX2
      Related
      ENSRNOP00000067835.3, ENSRNOT00000070818.5
      Conserved Domains (6) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:311363
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:711761
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:367549
      APP_E2; E2 domain of amyloid precursor protein
    2. NM_022520.1NP_071965.1  amyloid beta precursor like protein 2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon and encodes a shorter isoform (2), compared to variant 1.
      Source sequence(s)
      BP497339, CA340752, CB700594, CB795867, FM029818, FM030557, FM039816, FM041002, FM044356, FM104554, FM112636
      UniProtKB/Swiss-Prot
      P15943
      Related
      ENSRNOP00000067077.4, ENSRNOT00000074457.5
      Conserved Domains (6) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam00014
      Location:311363
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:49147
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam10515
      Location:699749
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:149204
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:367549
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      37857407..37920487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082084.1XP_038938012.1  amyloid beta precursor like protein 2 isoform X2

      UniProtKB/Swiss-Prot
      P15943
      UniProtKB/TrEMBL
      A6JYG1
      Conserved Domains (3) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:311493
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:614694
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins
    2. XM_039082083.1XP_038938011.1  amyloid beta precursor like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P15943
      UniProtKB/TrEMBL
      A0A8I5ZSU5
      Related
      ENSRNOP00000081588.1, ENSRNOT00000097481.2
      Conserved Domains (3) summary
      smart00006
      Location:42204
      A4_EXTRA; amyloid A4
      pfam12925
      Location:311493
      APP_E2; E2 domain of amyloid precursor protein
      cd21709
      Location:626706
      JMTM_APLP2; juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 2 (APLP-2) and similar proteins