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    Nrg1 neuregulin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 112400, updated on 28-Oct-2024

    Summary

    Official Symbol
    Nrg1provided by RGD
    Official Full Name
    neuregulin 1provided by RGD
    Primary source
    RGD:621341
    See related
    EnsemblRapid:ENSRNOG00000010392 AllianceGenome:RGD:621341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables receptor tyrosine kinase binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; cellular response to L-glutamate; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; extracellular space; and neuronal cell body. Used to study Alzheimer's disease and sciatic neuropathy. Biomarker of several diseases, including amblyopia; epilepsy (multiple); interstitial cystitis; neuropathy (multiple); and overactive bladder syndrome. Human ortholog(s) of this gene implicated in several diseases, including cannabis dependence; cerebral malaria; cerebrovascular disease (multiple); psychotic disorder (multiple); and substance abuse (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 31.6), Brain (RPKM 16.8) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nrg1 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (65954084..67007484)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (59250658..60304519)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (62969573..64065063)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2, pseudogene 1 Neighboring gene uncharacterized LOC120097371 Neighboring gene uncharacterized LOC120097372 Neighboring gene uncharacterized LOC134482402 Neighboring gene uncharacterized LOC102555473 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ErbB-2 class receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ErbB-3 class receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ErbB-3 class receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ErbB-3 class receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemorepellent activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERBB signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERBB signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ERBB2-ERBB3 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERBB2-ERBB3 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ERBB2-ERBB3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERBB2-ERBB4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ERBB2-ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERBB3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERBB4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERBB4-ERBB4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ERBB4-ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Schwann cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Schwann cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of protein kinase B activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in activation of transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cardiac conduction system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell apoptotic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to L-glutamate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to acetylcholine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to brain-derived neurotrophic factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to ciliary neurotrophic factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to potassium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to serotonin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within chemorepulsion involved in interneuron migration from the subpallium to the cortex ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocardial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocardial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glial cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in locomotory behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organismal response to stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within muscle organ development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myelination in peripheral nervous system ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of corticosterone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peripheral nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within peripheral nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Schwann cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axon regeneration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of striated muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynapse to nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to muscle activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sequestering of metal ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within synapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular trabecula myocardium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventricular trabecula myocardium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mossy fiber rosette ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pro-neuregulin-1, membrane-bound isoform
    Names
    glial growth factor
    neuregulin 1 type III beta 3
    pro-NRG1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271118.3NP_001258047.1  pro-neuregulin-1, membrane-bound isoform isoform 1

      See identical proteins and their annotated locations for NP_001258047.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2K3Q3, A6IVV2, Q9ESB1
      Related
      ENSRNOP00000072731.1, ENSRNOT00000081522.3
      Conserved Domains (2) summary
      PHA02887
      Location:237280
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:296688
      Neuregulin; Neuregulin family
    2. NM_001271119.3NP_001258048.1  pro-neuregulin-1, membrane-bound isoform isoform 2

      See identical proteins and their annotated locations for NP_001258048.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate coding exons and contains another alternate coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1, with the two isoforms containing an alternate internal segment.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2K057, A6IVV1, Q9ESB0
      Related
      ENSRNOP00000071312.1, ENSRNOT00000082355.3
      Conserved Domains (2) summary
      PHA02887
      Location:237279
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:291683
      Neuregulin; Neuregulin family
    3. NM_001271120.3NP_001258049.1  pro-neuregulin-1, membrane-bound isoform isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate coding exons and contains two other alternate coding exons compared to variant 1. The resulting isoform (3) contains an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVV4, G3V7D6
      Related
      ENSRNOP00000013991.6, ENSRNOT00000013991.10
      Conserved Domains (2) summary
      PHA02887
      Location:237279
      PHA02887; EGF-like protein; Provisional
      pfam02158
      Location:323479
      Neuregulin; Neuregulin family
    4. NM_001271121.3NP_001258050.1  pro-neuregulin-1, membrane-bound isoform isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      Q52NV2
      Conserved Domains (4) summary
      PHA03099
      Location:148237
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam00008
      Location:156186
      EGF; EGF-like domain
      cd05895
      Location:37129
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:230584
      Neuregulin; Neuregulin family
    5. NM_001271122.3NP_001258051.1  pro-neuregulin-1, membrane-bound isoform isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and contains an alternate exon compared to variant 1. The resulting isoform (5) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D3ZC94, Q52NV1
      Related
      ENSRNOP00000031467.6, ENSRNOT00000038549.9
      Conserved Domains (3) summary
      pfam00008
      Location:156186
      EGF; EGF-like domain
      cd05895
      Location:37129
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:238394
      Neuregulin; Neuregulin family
    6. NM_001271123.1NP_001258052.1  pro-neuregulin-1, membrane-bound isoform isoform 6

      See identical proteins and their annotated locations for NP_001258052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVV0
      Conserved Domains (2) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
    7. NM_001271124.1NP_001258053.1  pro-neuregulin-1, membrane-bound isoform isoform 7

      See identical proteins and their annotated locations for NP_001258053.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence, lacks two alternate coding exons, and contains another alternate coding exon compared to variant 1. The resulting isoform (7) has a shorter and distinct N-terminus, a shorter C-terminus, and contains an alternate internal segment compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVU8, A6IVU9
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:235422
      Neuregulin; Neuregulin family
    8. NM_001271125.3NP_001258054.1  pro-neuregulin-1, membrane-bound isoform isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence, lacks an alternate coding exon, and contains two other alternate coding exons compared to variant 1. The resulting isoform (8) contains an alternate internal segment and has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      Q52NV1
      Conserved Domains (3) summary
      pfam00008
      Location:190220
      EGF; EGF-like domain
      cd05895
      Location:37129
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:290446
      Neuregulin; Neuregulin family
    9. NM_001271126.3NP_001258055.1  pro-neuregulin-1, membrane-bound isoform isoform 9

      See identical proteins and their annotated locations for NP_001258055.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (9) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVU5, Q52NV3
      Related
      ENSRNOP00000077747.2, ENSRNOT00000099919.2
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:240632
      Neuregulin; Neuregulin family
    10. NM_001271127.3NP_001258056.1  pro-neuregulin-1, membrane-bound isoform isoform 10 preproprotein

      See identical proteins and their annotated locations for NP_001258056.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence, lacks an alternate coding exon, and contains another alternate coding exon compared to variant 1. The resulting isoform (10) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P43322, P43323, P43324, P43325, P43326, P43327, P43328
      UniProtKB/TrEMBL
      A6IVU4, G3V7F0
      Related
      ENSRNOP00000014268.5, ENSRNOT00000014268.10
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:258650
      Neuregulin; Neuregulin family
    11. NM_001271128.3NP_001258057.1  pro-neuregulin-1, membrane-bound isoform isoform 11

      See identical proteins and their annotated locations for NP_001258057.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence, lacks an alternate in-frame exon, and contains an alternate exon compared to variant 1. The resulting isoform (11) has shorter and distinct N- and C-termini and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVU7, A6IVU9
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:235423
      Neuregulin; Neuregulin family
    12. NM_001271129.4NP_001258058.1  pro-neuregulin-1, membrane-bound isoform isoform 12

      See identical proteins and their annotated locations for NP_001258058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (12) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVU3, Q52NV3
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam00008
      Location:190220
      EGF; EGF-like domain
      pfam02158
      Location:235627
      Neuregulin; Neuregulin family
    13. NM_001271130.3NP_001258059.1  pro-neuregulin-1, membrane-bound isoform isoform 14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (14) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      Q52NV3
      Conserved Domains (3) summary
      pfam00008
      Location:197227
      EGF; EGF-like domain
      cd05895
      Location:44136
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      pfam02158
      Location:279633
      Neuregulin; Neuregulin family
    14. NM_031588.4NP_113776.2  pro-neuregulin-1, membrane-bound isoform isoform 13

      See identical proteins and their annotated locations for NP_113776.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (13) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IVU6, Q52NV3
      Conserved Domains (4) summary
      cd05895
      Location:53127
      Ig_Pro_neuregulin-1; Immunoglobulin (Ig)-like domain found in neuregulin (NRG)-1
      PHA03099
      Location:182271
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      smart00410
      Location:43129
      IG_like; Immunoglobulin like
      pfam02158
      Location:232624
      Neuregulin; Neuregulin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      65954084..67007484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274979.1XP_063131049.1  pro-neuregulin-1, membrane-bound isoform isoform X5

    2. XM_063274980.1XP_063131050.1  pro-neuregulin-1, membrane-bound isoform isoform X6

    3. XM_063274978.1XP_063131048.1  pro-neuregulin-1, membrane-bound isoform isoform X2

    4. XM_063274982.1XP_063131052.1  pro-neuregulin-1, membrane-bound isoform isoform X8

    5. XM_017599969.3XP_017455458.1  pro-neuregulin-1, membrane-bound isoform isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKD3, A6IVV3, Q9ESB1
      Conserved Domains (2) summary
      PHA03099
      Location:238327
      PHA03099; epidermal growth factor-like protein (EGF-like protein); Provisional
      pfam02158
      Location:288680
      Neuregulin; Neuregulin family
    6. XM_017599971.3XP_017455460.1  pro-neuregulin-1, membrane-bound isoform isoform X3

      UniProtKB/TrEMBL
      A6IVV4
    7. XM_039094096.2XP_038950024.1  pro-neuregulin-1, membrane-bound isoform isoform X4

      UniProtKB/TrEMBL
      A6IVV4
      Conserved Domains (2) summary
      pfam02158
      Location:320476
      Neuregulin; Neuregulin family
      NF033760
      Location:127223
      gliding_GltG; adventurous gliding motility protein GltG
    8. XM_063274981.1XP_063131051.1  pro-neuregulin-1, membrane-bound isoform isoform X7