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    Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293652, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Ndufs8provided by RGD
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S8provided by RGD
    Primary source
    RGD:1309436
    See related
    EnsemblRapid:ENSRNOG00000017446 AllianceGenome:RGD:1309436
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; and response to oxidative stress. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 1099.0), Muscle (RPKM 682.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndufs8 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210569823..210573707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201140585..201144573, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219141289..219144610, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene choline kinase alpha Neighboring gene T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 Neighboring gene aldehyde dehydrogenase 3 family, member B1 Neighboring gene unc-93 homolog B1, TLR signaling regulator Neighboring gene aldehyde dehydrogenase 3 family, member B3 Neighboring gene aldehyde dehydrogenase 3 family, member B3-like, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Late-onset Leigh syndrome in a patient with mitochondrial complex I NDUFS8 mutations. Procaccio V, et al. Neurology, 2004 May 25. PMID 15159508, Free PMC Article
    2. The first nuclear-encoded complex I mutation in a patient with Leigh syndrome. Loeffen J, et al. Am J Hum Genet, 1998 Dec. PMID 9837812, Free PMC Article
    3. Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase. de Sury R, et al. Gene, 1998 Jul 17. PMID 9666055
    4. Mutations in the complex I NDUFS2 gene of patients with cardiomyopathy and encephalomyopathy. Loeffen J, et al. Ann Neurol, 2001 Feb. PMID 11220739
    5. Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency. Ugalde C, et al. Hum Mol Genet, 2004 Mar 15. PMID 14749350

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) Fe-S protein 8
    NP_001099792.1
    XP_006230793.1
    XP_017444503.1
    XP_038964139.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106322.2 → NP_001099792.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

      See identical proteins and their annotated locations for NP_001099792.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158791
      UniProtKB/TrEMBL
      B0BNE6, F7FGW7
      Related
      ENSRNOP00000023526.5, ENSRNOT00000023526.7
      Conserved Domains (1) summary
      PRK05888
      Location:57 → 212
      PRK05888; NADH-quinone oxidoreductase subunit NuoI

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210569823..210573707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230731.3 → XP_006230793.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006230793.1

      UniProtKB/TrEMBL
      B0BNE6, F7FGW7
      Conserved Domains (1) summary
      PRK05888
      Location:57 → 212
      PRK05888; NADH-quinone oxidoreductase subunit NuoI

    2. XM_039108211.2 → XP_038964139.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B0BNE6, F7FGW7
      Conserved Domains (1) summary
      PRK05888
      Location:57 → 212
      PRK05888; NADH-quinone oxidoreductase subunit NuoI

    3. XM_017589014.3 → XP_017444503.1  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B0BNE6, F7FGW7
      Conserved Domains (1) summary
      PRK05888
      Location:57 → 212
      PRK05888; NADH-quinone oxidoreductase subunit NuoI
    Nucleotide Protein Strain
    Heading Accession and Version

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