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    Mtx2 metaxin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288150, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mtx2provided by RGD
    Official Full Name
    metaxin 2provided by RGD
    Primary source
    RGD:1306473
    See related
    EnsemblRapid:ENSRNOG00000001559 AllianceGenome:RGD:1306473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrial transport and mitochondrion organization. Predicted to be located in mitochondrion and nucleolus. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 165.3), Testes (RPKM 127.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtx2 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (80137556..80199547)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (59730206..59792202)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (61756109..61818999)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene homeo box D1 Neighboring gene uncharacterized LOC134486290 Neighboring gene uncharacterized LOC134486383 Neighboring gene uncharacterized LOC134486384

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
    2. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article
    3. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106000

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metaxin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008286.2 → NP_001008287.1  metaxin-2 isoform 1

      See identical proteins and their annotated locations for NP_001008287.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6APV3, F7FAZ7, Q5U1Z9
      Related
      ENSRNOP00000104904.1, ENSRNOT00000141147.1
      Conserved Domains (3) summary
      cd03211
      Location:125 → 250
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      COG0625
      Location:33 → 251
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03079
      Location:22 → 95
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...

    2. NM_001429821.1 → NP_001416750.1  metaxin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZLV1

    3. NM_001429822.1 → NP_001416751.1  metaxin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      80137556..80199547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234371.5 → XP_006234433.1  metaxin-2 isoform X2

      Related
      ENSRNOP00000095766.2, ENSRNOT00000097639.2
      Conserved Domains (2) summary
      cd03079
      Location:22 → 95
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...
      cl02776
      Location:125 → 213
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_006234370.5 → XP_006234432.1  metaxin-2 isoform X1

      Related
      ENSRNOP00000078996.1, ENSRNOT00000115991.2
      Conserved Domains (3) summary
      cd03211
      Location:122 → 247
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      COG0625
      Location:30 → 248
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03079
      Location:19 → 92
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...

    3. XM_039104413.2 → XP_038960341.1  metaxin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6APV3
      Conserved Domains (2) summary
      cd03211
      Location:76 → 201
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      pfam10568
      Location:1 → 113
      Tom37; Outer mitochondrial membrane transport complex protein

    4. XM_039104412.2 → XP_038960340.1  metaxin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6APV3
      Conserved Domains (2) summary
      cd03211
      Location:76 → 201
      GST_C_Metaxin2; C-terminal, alpha helical domain of Metaxin 2
      pfam10568
      Location:1 → 113
      Tom37; Outer mitochondrial membrane transport complex protein
    Nucleotide Protein Strain
    Heading Accession and Version

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