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    Slc44a2 solute carrier family 44 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363024, updated on 2-May-2024

    Summary

    Official Symbol
    Slc44a2provided by RGD
    Official Full Name
    solute carrier family 44 member 2provided by RGD
    Primary source
    RGD:1309680
    See related
    Ensembl:ENSRNOG00000031824 AllianceGenome:RGD:1309680
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309680
    Summary
    Predicted to enable choline transmembrane transporter activity. Predicted to be involved in choline transport; positive regulation of I-kappaB kinase/NF-kappaB signaling; and transmembrane transport. Predicted to be located in mitochondrion and plasma membrane. Predicted to be active in membrane. Orthologous to human SLC44A2 (solute carrier family 44 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 404.4), Lung (RPKM 336.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    8q13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28147023..28181496)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (19870867..19905345)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22351277..22385869)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 2D Neighboring gene adaptor related protein complex 1 subunit mu 2 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC187957

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choline transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables choline transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ethanolamine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ethanolamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ethanolamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables quaternary ammonium group transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables salt transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in choline transport IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ethanolamine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ethanolamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ethanolamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in organic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in quaternary ammonium group transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    choline transporter-like protein 2
    Names
    solute carrier family 44 (choline transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134715.1NP_001128187.1  choline transporter-like protein 2

      See identical proteins and their annotated locations for NP_001128187.1

      Status: VALIDATED

      Source sequence(s)
      BC168183
      UniProtKB/Swiss-Prot
      B4F795
      Conserved Domains (1) summary
      pfam04515
      Location:319674
      Choline_transpo; Plasma-membrane choline transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28147023..28181496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265729.1XP_063121799.1  choline transporter-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G961
    2. XM_006242651.4XP_006242713.1  choline transporter-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006242713.1

      UniProtKB/TrEMBL
      A0A8I5ZYC2, A6JNR3
      Related
      ENSRNOP00000083031.1, ENSRNOT00000109509.1
      Conserved Domains (1) summary
      pfam04515
      Location:317672
      Choline_transpo; Plasma-membrane choline transporter
    3. XM_063265728.1XP_063121798.1  choline transporter-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QQY0
    4. XM_039081711.2XP_038937639.1  choline transporter-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QQY0
      Conserved Domains (1) summary
      pfam04515
      Location:320675
      Choline_transpo; Plasma-membrane choline transporter