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    Ash2l ASH2 like histone lysine methyltransferase complex subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290829, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Ash2lprovided by RGD
    Official Full Name
    ASH2 like histone lysine methyltransferase complex subunitprovided by RGD
    Primary source
    RGD:1305632
    See related
    EnsemblRapid:ENSRNOG00000014875 AllianceGenome:RGD:1305632
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to histone methyltransferase activity (H3-K4 specific). Predicted to be involved in histone H3-K4 methylation; positive regulation of cell population proliferation; and response to estrogen. Predicted to act upstream of or within cellular response to DNA damage stimulus and positive regulation of transcription by RNA polymerase II. Predicted to be located in euchromatin and nucleus. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Biomarker of schizophrenia. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 357.7), Thymus (RPKM 167.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ash2l in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (72943527..72966791)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66242205..66264064)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71011315..71033171)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 5 Neighboring gene potassium calcium-activated channel subfamily U member 1 Neighboring gene uncharacterized LOC120097390 Neighboring gene steroidogenic acute regulatory protein Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene BAG cochaperone 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human trithorax protein hASH2 functions as an oncoprotein. Lüscher-Firzlaff J, et al. Cancer Res, 2008 Feb 1. PMID 18245475
    2. Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex. Maćkowiak M, et al. Eur Neuropsychopharmacol, 2014 Feb. PMID 23932495
    3. Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. Mo R, et al. J Biol Chem, 2006 Jun 9. PMID 16603732
    4. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. Patel A, et al. J Biol Chem, 2009 Sep 4. PMID 19556245, Free PMC Article
    5. Ash2l interacts with Tbx1 and is required during early embryogenesis. Stoller JZ, et al. Exp Biol Med (Maywood), 2010 May. PMID 20463296, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    set1/Ash2 histone methyltransferase complex subunit ASH2
    Names
    ash2 (absent, small, or homeotic)-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106089.1 → NP_001099559.1  set1/Ash2 histone methyltransferase complex subunit ASH2

      See identical proteins and their annotated locations for NP_001099559.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473970
      UniProtKB/TrEMBL
      A0A8I6ASM7, A6IW01
      Related
      ENSRNOP00000020181.6, ENSRNOT00000020181.9
      Conserved Domains (2) summary
      cd15583
      Location:96 → 145
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:387 → 578
      SPRY_Ash2; SPRY domain in Ash2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      72943527..72966791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253303.4 → XP_006253365.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASM7, D3ZTV7
      Related
      ENSRNOP00000068617.3, ENSRNOT00000086891.3
      Conserved Domains (2) summary
      cd15583
      Location:96 → 145
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:393 → 584
      SPRY_Ash2; SPRY domain in Ash2

    2. XM_006253304.5 → XP_006253366.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JT90
      Conserved Domains (2) summary
      cd15583
      Location:7 → 56
      PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
      cd12872
      Location:304 → 495
      SPRY_Ash2; SPRY domain in Ash2

    3. XM_063275243.1 → XP_063131313.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X3

      Related
      ENSRNOP00000105188.1, ENSRNOT00000154128.1
    Nucleotide Protein Strain
    Heading Accession and Version

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