Vac14 VAC14 component of PIKFYVE complex [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vac14provided by RGD
Official Full Name: VAC14 component of PIKFYVE complexprovided by RGD
Primary source: RGD:631410
See related: Ensembl:ENSRNOG00000017219 AllianceGenome:RGD:631410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in phosphatidylinositol biosynthetic process and positive regulation of kinase activity. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of PAS complex. Predicted to be active in endosome membrane. Predicted to be extrinsic component of vacuolar membrane. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 93.9), Kidney (RPKM 82.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (55499962..55601290)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (38590569..38691911)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (40927007..41029206, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI008813 (e-PCR)
- UniSTS:250656

RH137884 (e-PCR)
- UniSTS:219971

BF406165 (e-PCR)
- UniSTS:248297

BE101741 (e-PCR)
- UniSTS:243705

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PAS complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein VAC14 homolog

Names: Vac14 homolog; Vac14, PIKFYVE complex component; vacuole 14 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177930.3 → NP_808791.1 protein VAC14 homolog

See identical proteins and their annotated locations for NP_808791.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q80W92

UniProtKB/TrEMBL

A6IZ63, A6IZ64

Related

ENSRNOP00000023383.4, ENSRNOT00000023383.6

Conserved Domains (3) summary

pfam11916
Location:544 → 718

Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding

pfam12755
Location:67 → 163

Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region

sd00044
Location:94 → 122

HEAT; HEAT repeat [structural motif]