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    Ndfip2 Nedd4 family interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361089, updated on 28-Oct-2024

    Summary

    Official Symbol
    Ndfip2provided by RGD
    Official Full Name
    Nedd4 family interacting protein 2provided by RGD
    Primary source
    RGD:1309716
    See related
    EnsemblRapid:ENSRNOG00000024022 AllianceGenome:RGD:1309716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable WW domain binding activity. Predicted to be involved in several processes, including negative regulation of transport; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of protein ubiquitination. Predicted to be located in mitochondrion. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Orthologous to human NDFIP2 (Nedd4 family interacting protein 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 280.0), Kidney (RPKM 215.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ndfip2 in Genome Data Viewer
    Location:
    15q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (88394548..88500881)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (82032366..82087043)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (89407426..89458983)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene ribosomal protein S11, pseudogene 8 Neighboring gene uncharacterized LOC134482160 Neighboring gene uncharacterized LOC120097070 Neighboring gene uncharacterized LOC134482161 Neighboring gene transfer RNA proline (anticodon AGG) 90 Neighboring gene ribosomal protein L9, pseudogene 14 Neighboring gene small ribosomal subunit protein uS15-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NEDD4 family-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108390.2NP_001101860.2  NEDD4 family-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      BP495172, CB697675, CO398212, DV728397, DY565248, FM044778
      UniProtKB/TrEMBL
      F1M1W4
      Related
      ENSRNOP00000032094.6, ENSRNOT00000039423.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      88394548..88500881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274468.1XP_063130538.1  NEDD4 family-interacting protein 2 isoform X1

      Related
      ENSRNOP00000078524.2, ENSRNOT00000104952.2
    2. XM_063274469.1XP_063130539.1  NEDD4 family-interacting protein 2 isoform X1