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    Nol12 nucleolar protein 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362955, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nol12provided by RGD
    Official Full Name
    nucleolar protein 12provided by RGD
    Primary source
    RGD:1305327
    See related
    EnsemblRapid:ENSRNOG00000010209 AllianceGenome:RGD:1305327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nop25; RGD1305327
    Summary
    Enables rRNA binding activity and single-stranded DNA binding activity. Located in nucleolus. Orthologous to human NOL12 (nucleolar protein 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 16.2), Thymus (RPKM 14.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nol12 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112373749..112379362)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110493294..110498908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120161238..120166852)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479755 Neighboring gene pyridoxal phosphatase Neighboring gene galectin 1 Neighboring gene TRIO and F-actin binding protein Neighboring gene H1.0 linker histone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25. Fujiwara T, et al. Exp Cell Res, 2006 Jun 10. PMID 16515785
    2. Molecular cloning and characterization of Nop25, a novel nucleolar RNA binding protein, highly conserved in vertebrate species. Suzuki S, et al. Exp Cell Res, 2006 Apr 15. PMID 16430885
    3. Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing. Sloan KE, et al. J Cell Biol, 2013 Mar 4. PMID 23439679, Free PMC Article
    4. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, et al. Wiley Interdiscip Rev RNA, 2015 Mar-Apr. PMID 25346433, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC124902

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 12
    Names
    25 kDa nucleolar protein
    nucleolar protein, 25 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012747.2 → NP_001012765.1  nucleolar protein 12

      See identical proteins and their annotated locations for NP_001012765.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103643
      UniProtKB/Swiss-Prot
      Q5D1Z3
      UniProtKB/TrEMBL
      A6HSN5
      Conserved Domains (1) summary
      pfam09805
      Location:20 → 67
      Nop25; Nucleolar protein 12 (25kDa)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112373749..112379362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263916.1 → XP_063119986.1  nucleolar protein 12 isoform X2

    2. XM_006242007.4 → XP_006242069.1  nucleolar protein 12 isoform X1

      Related
      ENSRNOP00000013764.4, ENSRNOT00000013764.8
      Conserved Domains (1) summary
      pfam09805
      Location:67 → 105
      Nop25; Nucleolar protein 12 (25kDa)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5D1Z3.1 GenPept UniProtKB/Swiss-Prot:Q5D1Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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