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    Slitrk1 SLIT and NTRK-like family, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306147, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slitrk1provided by RGD
    Official Full Name
    SLIT and NTRK-like family, member 1provided by RGD
    Primary source
    RGD:1308858
    See related
    EnsemblRapid:ENSRNOG00000009209 AllianceGenome:RGD:1308858
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in regulation of synapse organization. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and trichotillomania. Orthologous to human SLITRK1 (SLIT and NTRK like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Slitrk1 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (92137703..92141741, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (85723252..85727290, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (93303382..93307420, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 8 Neighboring gene apolipoprotein O-like, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of SLITRK1 variation in obsessive-compulsive disorder. Ozomaro U, et al. PLoS One, 2013. PMID 23990902, Free PMC Article
    2. Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. Katayama K, et al. Mol Psychiatry, 2010 Feb. PMID 18794888
    3. Slitrk1 is localized to excitatory synapses and promotes their development. Beaubien F, et al. Sci Rep, 2016 Jun 7. PMID 27273464, Free PMC Article
    4. A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity. Schroeder A, et al. Neuron, 2018 Jul 25. PMID 29983322
    5. Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. Yim YS, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23345436, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homeostatic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within norepinephrine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SLIT and NTRK-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107283.1 → NP_001100753.1  SLIT and NTRK-like protein 1 precursor

      See identical proteins and their annotated locations for NP_001100753.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HUD1, D3Z8D8
      Related
      ENSRNOP00000012195.5, ENSRNOT00000012195.7
      Conserved Domains (3) summary
      sd00033
      Location:62 → 83
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:425 → 483
      LRR_8; Leucine rich repeat
      cl15307
      Location:212 → 250
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      92137703..92141741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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