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    Mrgbp MRG domain binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311713, updated on 3-Apr-2024

    Summary

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    Symbol
    Mrgbpprovided by RGD
    Full Name
    MRG domain binding proteinprovided by RGD
    Primary source
    RGD:1308612
    See related
    Ensembl:ENSRNOG00000059891 AllianceGenome:RGD:1308612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308612
    Summary
    Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of NuA4 histone acetyltransferase complex. Orthologous to human MRGBP (MRG domain binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 190.5), Thymus (RPKM 137.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrgbp in Genome Data Viewer
    Location:
    3q43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188074695..188078162)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167697129..167700592)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175924456..175927925)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486515 Neighboring gene uncharacterized LOC102552550 Neighboring gene neurotensin receptor 1 Neighboring gene 60S ribosomal protein L17-like Neighboring gene opioid growth factor receptor Neighboring gene collagen type IX alpha 3 chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116321

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MRG/MORF4L-binding protein
    Names
    MRG-binding protein
    MRG/MORF4L binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173739.1 → NP_001167210.1  MRG/MORF4L-binding protein

      See identical proteins and their annotated locations for NP_001167210.1

      Status: VALIDATED

      Source sequence(s)
      BC099155, CO403993
      UniProtKB/TrEMBL
      A6KM92, G3V751
      Related
      ENSRNOP00000070225.1, ENSRNOT00000086626.2
      Conserved Domains (1) summary
      pfam07904
      Location:36 → 94
      Eaf7; Chromatin modification-related protein EAF7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188074695..188078162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283891.1 → XP_063139961.1  MRG/MORF4L-binding protein isoform X1

      UniProtKB/TrEMBL
      A6KM93

    2. XM_063283894.1 → XP_063139964.1  MRG/MORF4L-binding protein isoform X3

      UniProtKB/TrEMBL
      A6KM94

    3. XM_063283892.1 → XP_063139962.1  MRG/MORF4L-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AAD6, A6KM95
    Nucleotide Protein Strain
    Heading Accession and Version

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