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    Mtfr1 mitochondrial fission regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311403, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Mtfr1provided by RGD
    Official Full Name
    mitochondrial fission regulator 1provided by RGD
    Primary source
    RGD:1304936
    See related
    Ensembl:ENSRNOG00000021359 AllianceGenome:RGD:1304936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304936
    Summary
    Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be located in cytosol and plasma membrane. Predicted to be active in mitochondrion. Orthologous to human MTFR1 (mitochondrial fission regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 105.6), Testes (RPKM 93.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtfr1 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (103594458..103629697)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (101678331..101713547)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (104005696..104040914)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100569 Neighboring gene armadillo repeat containing 1 Neighboring gene phosphodiesterase 7A Neighboring gene RAB5C, member RAS oncogene family, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis. Huang L, et al. IUBMB Life, 2020 Mar. PMID 31622017
    2. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. Monticone M, et al. J Cell Physiol, 2010 Nov. PMID 20568109
    3. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis.
      Title: Inhibition of the LncRNA Gpr19 attenuates ischemia-reperfusion injury after acute myocardial infarction by inhibiting apoptosis and oxidative stress via the miR-324-5p/Mtfr1 axis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aerobic respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial fission regulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100977.2 → NP_001094447.2  mitochondrial fission regulator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026
      Related
      ENSRNOP00000040894.3, ENSRNOT00000045586.4
      Conserved Domains (1) summary
      pfam05308
      Location:24 → 253
      Mito_fiss_reg; Mitochondrial fission regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      103594458..103629697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232179.5 → XP_006232241.1  mitochondrial fission regulator 1 isoform X1

      See identical proteins and their annotated locations for XP_006232241.1

      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026
      Conserved Domains (1) summary
      pfam05308
      Location:24 → 253
      Mito_fiss_reg; Mitochondrial fission regulator

    2. XM_063281996.1 → XP_063138066.1  mitochondrial fission regulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026

    3. XM_063281993.1 → XP_063138063.1  mitochondrial fission regulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026

    4. XM_063281997.1 → XP_063138067.1  mitochondrial fission regulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026

    5. XM_063281994.1 → XP_063138064.1  mitochondrial fission regulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026

    6. XM_063281995.1 → XP_063138065.1  mitochondrial fission regulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026

    7. XM_063281998.1 → XP_063138068.1  mitochondrial fission regulator 1 isoform X1

      UniProtKB/Swiss-Prot
      A3F823, G3V9A7
      UniProtKB/TrEMBL
      A0A8I6A026

    8. XM_006232180.5 → XP_006232242.1  mitochondrial fission regulator 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A026, A0A8I6A6A8
      Related
      ENSRNOP00000086488.1
      Conserved Domains (1) summary
      pfam05308
      Location:5 → 234
      Mito_fiss_reg; Mitochondrial fission regulator

    9. XM_063281992.1 → XP_063138062.1  mitochondrial fission regulator 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A026
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V9A7.1 GenPept UniProtKB/Swiss-Prot:G3V9A7

    Gene LinkOut

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