Sdsl serine dehydratase-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sdslprovided by RGD
Official Full Name: serine dehydratase-likeprovided by RGD
Primary source: RGD:1309192
See related: EnsemblRapid:ENSRNOG00000001391 AllianceGenome:RGD:1309192
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TDH; Sdhl
Summary: Enables ammonia-lyase activity; glutamate racemase activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine catabolic process; isoleucine biosynthetic process; and threonine catabolic process. Orthologous to human SDSL (serine dehydratase like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 26.1), Testes (RPKM 13.6) and 5 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (41760252..41770465)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (36099693..36109914)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (41636994..41647205)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Sdsl (e-PCR), detects polymorphism
- UniSTS:471098

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-serine ammonia-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-serine ammonia-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-serine ammonia-lyase activity	ISO Inferred from Sequence Orthology more info
enables glutamate racemase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables threonine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables threonine deaminase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-serine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in isoleucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in threonine catabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: serine dehydratase-like

Names: L-serine deaminase; L-serine dehydratase-like; L-serine dehydratase/L-threonine deaminase; L-threonine dehydratase; glutamate racemase

NP_001101806.1

EC 4.3.1.17

EC 4.3.1.19

EC 5.1.1.3

XP_038945528.1

EC 4.3.1.17

EC 4.3.1.19

EC 5.1.1.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108336.1 → NP_001101806.1 serine dehydratase-like

See identical proteins and their annotated locations for NP_001101806.1

Status: PROVISIONAL

Source sequence(s)

CH473973

UniProtKB/Swiss-Prot

A0A6N3IN21, D3ZHV7

Related

ENSRNOP00000001882.9, ENSRNOT00000001882.8

Conserved Domains (1) summary

cd06448
Location:17 → 326

L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

41760252..41770465

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089600.2 → XP_038945528.1 serine dehydratase-like isoform X1

Conserved Domains (1) summary

cl00342
Location:22 → 276

Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...