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    Acin1 apoptotic chromatin condensation inducer 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305884, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Acin1provided by RGD
    Official Full Name
    apoptotic chromatin condensation inducer 1provided by RGD
    Primary source
    RGD:1311945
    See related
    EnsemblRapid:ENSRNOG00000013533 AllianceGenome:RGD:1311945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including apoptotic chromosome condensation; negative regulation of mRNA splicing, via spliceosome; and positive regulation of monocyte differentiation. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of ASAP complex and exon-exon junction complex. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 247.0), Adrenal (RPKM 218.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acin1 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32072121..32117004, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28102112..28147001, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33288369..33333256, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene cadherin 24 Neighboring gene similar to human chromosome 14 open reading frame 119 Neighboring gene ciliated left-right organizer metallopeptidase Neighboring gene CCAAT/enhancer binding protein epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Specific involvement of caspases in the differentiation of monocytes into macrophages. Sordet O, et al. Blood, 2002 Dec 15. PMID 12393560
    2. Caspase activation is required for terminal erythroid differentiation. Zermati Y, et al. J Exp Med, 2001 Jan 15. PMID 11208865, Free PMC Article
    3. AMPA-induced excitotoxicity increases nuclear levels of CAD, endonuclease G, and acinus and induces chromatin condensation in rat hippocampal pyramidal neurons. Henne WM, et al. Cell Mol Neurobiol, 2006 May. PMID 16767516
    4. Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. Singh KK, et al. RNA, 2010 Dec. PMID 20966198, Free PMC Article
    5. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Sahara S, et al. Nature, 1999 Sep 9. PMID 10490026

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ASAP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptotic chromatin condensation inducer in the nucleus
    Names
    acinus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170468.1 → NP_001163939.1  apoptotic chromatin condensation inducer in the nucleus

      Status: VALIDATED

      Source sequence(s)
      AA925536, AI575776, CA512047, CB744719, CF110347, EV770592, FM029308, FM031419, FM033220, JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AU50, E9PST5
      Related
      ENSRNOP00000018982.4, ENSRNOT00000018982.8
      Conserved Domains (3) summary
      smart00513
      Location:72 → 106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:1011 → 1097
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:1165 → 1240
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32072121..32117004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274245.1 → XP_063130315.1  apoptotic chromatin condensation inducer in the nucleus isoform X16

    2. XM_063274243.1 → XP_063130313.1  apoptotic chromatin condensation inducer in the nucleus isoform X14

    3. XM_063274240.1 → XP_063130310.1  apoptotic chromatin condensation inducer in the nucleus isoform X11

      Related
      ENSRNOP00000076634.2, ENSRNOT00000109889.2

    4. XM_063274241.1 → XP_063130311.1  apoptotic chromatin condensation inducer in the nucleus isoform X12

    5. XM_063274239.1 → XP_063130309.1  apoptotic chromatin condensation inducer in the nucleus isoform X6

    6. XM_006251960.5 → XP_006252022.1  apoptotic chromatin condensation inducer in the nucleus isoform X10

      UniProtKB/TrEMBL
      A0A8I5Y5F2, A0A8I6AU50
      Conserved Domains (3) summary
      smart00513
      Location:72 → 106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:971 → 1057
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:1125 → 1200
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    7. XM_063274237.1 → XP_063130307.1  apoptotic chromatin condensation inducer in the nucleus isoform X4

    8. XM_063274242.1 → XP_063130312.1  apoptotic chromatin condensation inducer in the nucleus isoform X13

      Related
      ENSRNOP00000096887.2, ENSRNOT00000112466.2

    9. XM_006251959.5 → XP_006252021.1  apoptotic chromatin condensation inducer in the nucleus isoform X9

      UniProtKB/TrEMBL
      A0A8I6AU50
      Conserved Domains (3) summary
      smart00513
      Location:72 → 106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:998 → 1084
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:1152 → 1227
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    10. XM_017599684.3 → XP_017455173.1  apoptotic chromatin condensation inducer in the nucleus isoform X7

      UniProtKB/TrEMBL
      A0A8I6AU50

    11. XM_063274235.1 → XP_063130305.1  apoptotic chromatin condensation inducer in the nucleus isoform X2

    12. XM_063274238.1 → XP_063130308.1  apoptotic chromatin condensation inducer in the nucleus isoform X5

    13. XM_006251958.5 → XP_006252020.1  apoptotic chromatin condensation inducer in the nucleus isoform X8

      UniProtKB/TrEMBL
      A0A8I6AU50
      Conserved Domains (3) summary
      smart00513
      Location:72 → 106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd12432
      Location:999 → 1085
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:1153 → 1228
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    14. XM_063274236.1 → XP_063130306.1  apoptotic chromatin condensation inducer in the nucleus isoform X3

    15. XM_063274234.1 → XP_063130304.1  apoptotic chromatin condensation inducer in the nucleus isoform X1

    16. XM_063274244.1 → XP_063130314.1  apoptotic chromatin condensation inducer in the nucleus isoform X15

    17. XM_063274247.1 → XP_063130317.1  apoptotic chromatin condensation inducer in the nucleus isoform X20

    18. XM_006251963.4 → XP_006252025.1  apoptotic chromatin condensation inducer in the nucleus isoform X19

      Related
      ENSRNOP00000090495.1, ENSRNOT00000111598.2
      Conserved Domains (2) summary
      cd12432
      Location:253 → 339
      RRM_ACINU; RNA recognition motif in apoptotic chromatin condensation inducer in the nucleus (acinus) and similar proteins
      pfam16294
      Location:407 → 482
      RSB_motif; RNSP1-SAP18 binding (RSB) motif

    19. XM_063274246.1 → XP_063130316.1  apoptotic chromatin condensation inducer in the nucleus isoform X17

    20. XM_039093289.2 → XP_038949217.1  apoptotic chromatin condensation inducer in the nucleus isoform X18

      Conserved Domains (2) summary
      smart00513
      Location:72 → 106
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      NF033804
      Location:680 → 816
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin

    RNA

    1. XR_010057814.1 RNA Sequence

    2. XR_005493719.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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