Gpc3 glypican 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpc3provided by RGD
Official Full Name: glypican 3provided by RGD
Primary source: RGD:2725
See related: EnsemblRapid:ENSRNOG00000060179 AllianceGenome:RGD:2725
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: OCI-5
Summary: Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 1010.0), Kidney (RPKM 338.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (136789770..137157598, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (131868986..132236824, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (139579268..139947093, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Abnormal oncofetal antigen GPC-3 and GPC-3 mRNA expression in hepatocarcinogenesis may be promising molecular markers for early diagnosis of hepatocellular carcinoma.
Title: Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma.
GPC3 may be a negative regulator of liver regeneration and hepatocyte proliferation, and that this regulation may involve CD81.
Title: Investigation of the role of glypican 3 in liver regeneration and hepatocyte proliferation.
Gpc3 is a marker of hepatic progenitor cells and of early liver lesions.
Title: The oncofetal protein glypican-3 is a novel marker of hepatic progenitor/oval cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gpc3 (e-PCR), detects polymorphism
- UniSTS:516102

L77880 (e-PCR)
- UniSTS:3642

DXWox36 (e-PCR)
- UniSTS:240186

Gpc3 (e-PCR), detects polymorphism
- UniSTS:498501

AL032586 (e-PCR)
- UniSTS:93261

RH138426 (e-PCR)
- UniSTS:220513

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidyl-dipeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-dipeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway, planar cell polarity pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in body morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration involved in gastrulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell proliferation involved in kidney development	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation involved in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell proliferation involved in metanephros development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell proliferation involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in coronary vasculature development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within coronary vasculature development	ISO Inferred from Sequence Orthology more info
involved_in coronary vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell proliferation involved in ureteric bud development	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal cell proliferation involved in ureteric bud development	ISO Inferred from Sequence Orthology more info
involved_in mesonephric duct morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesonephric duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mesonephric duct morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glypican-3

Names: defective in Simpson-Golabi-Behmel overgrowth syndrome; intestinal protein OCI-5; proteoglycan GPC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012774.2 → NP_036906.2 glypican-3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

P13265, Q5U326

UniProtKB/TrEMBL

A0A0G2KBA2, A6JMU0

Related

ENSRNOP00000075712.2, ENSRNOT00000090442.3

Conserved Domains (1) summary

pfam01153
Location:14 → 576

Glypican