Gcdh glutaryl-CoA dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gcdhprovided by RGD
Official Full Name: glutaryl-CoA dehydrogenaseprovided by RGD
Primary source: RGD:1308829
See related: EnsemblRapid:ENSRNOG00000003307 AllianceGenome:RGD:1308829
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Involved in fatty acid oxidation and fatty-acyl-CoA biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1777.2), Liver (RPKM 1242.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40168038..40174536)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23263215..23269689)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26000497..26006970, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery.
Title: The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery.
GCDH was found widely expressed in embryonic and adult rat tissues. In rat embryos GCDH is predominantly expressed in brain implying an important role for brain development. Interestingly, GCDH was found to be significantly expressed in different other organs (e.g. kidney, gut) in adult rats probably explaining the evolving phenotype in GA-I patients.
Title: Immunolocalization of glutaryl-CoA dehydrogenase (GCDH) in adult and embryonic rat brain and peripheral tissues.
GA1-induced striatal degeneration is partially caspase-dependent
Title: Effects of targeted suppression of glutaryl-CoA dehydrogenase by lentivirus-mediated shRNA and excessive intake of lysine on apoptosis in rat striatal neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143238 (e-PCR)
- UniSTS:232485

RH137276 (e-PCR)
- UniSTS:219364

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables glutaryl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutaryl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutaryl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info
involved_in fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty-acyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty-acyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutaryl-CoA dehydrogenase, mitochondrial

Names: glutaryl-Coenzyme A dehydrogenase

NP_001102366.1

EC 1.3.8.6

XP_063134240.1

EC 1.3.8.6

XP_063134241.1

EC 1.3.8.6

XP_063134242.1

EC 1.3.8.6

XP_063134243.1

EC 1.3.8.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108896.1 → NP_001102366.1 glutaryl-CoA dehydrogenase, mitochondrial

Status: PROVISIONAL

Source sequence(s)

CH473972

UniProtKB/TrEMBL

A0A8I5ZN89, A6IY64

Related

ENSRNOP00000079491.2, ENSRNOT00000103013.2

Conserved Domains (2) summary

cd01151
Location:57 → 443

GCD; Glutaryl-CoA dehydrogenase

COG1960
Location:69 → 443

CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

40168038..40174536

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278170.1 → XP_063134240.1 glutaryl-CoA dehydrogenase, mitochondrial isoform X1

UniProtKB/TrEMBL

D3ZT90
XM_063278171.1 → XP_063134241.1 glutaryl-CoA dehydrogenase, mitochondrial isoform X2

UniProtKB/TrEMBL

D3ZT90
XM_063278172.1 → XP_063134242.1 glutaryl-CoA dehydrogenase, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8I5ZN89
XM_063278173.1 → XP_063134243.1 glutaryl-CoA dehydrogenase, mitochondrial isoform X4

UniProtKB/TrEMBL

D3ZT90