U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Trpv5 transient receptor potential cation channel, subfamily V, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116469, updated on 28-Oct-2024

    Summary

    Official Symbol
    Trpv5provided by RGD
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 5provided by RGD
    Primary source
    RGD:620636
    See related
    EnsemblRapid:ENSRNOG00000015394 AllianceGenome:RGD:620636
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CaT2; Ecac1
    Summary
    Enables calcium channel activity. Involved in calcium ion transport into cytosol. Located in apical plasma membrane. Orthologous to human TRPV5 (transient receptor potential cation channel subfamily V member 5). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward (RPKM 50.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trpv5 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (71503085..71531134, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (70536432..70562743, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70947615..70974004, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Eph receptor B6 Neighboring gene transient receptor potential cation channel, subfamily V, member 6 Neighboring gene LLLL and CFNLAS motif containing 1 Neighboring gene Kell metallo-endopeptidase (Kell blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion transport into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of urine volume ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    transient receptor potential cation channel subfamily V member 5
    Names
    OTRPC3
    calcium transporter 2
    epithelial calcium channel 1
    osm-9-like TRP channel 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053787.3NP_446239.3  transient receptor potential cation channel subfamily V member 5

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q5UC98, Q9JIP0, Q9JJL2
      UniProtKB/TrEMBL
      A6IF48
      Related
      ENSRNOP00000020975.2, ENSRNOT00000020975.7
      Conserved Domains (3) summary
      sd00045
      Location:111154
      ANK; ANK repeat [structural motif]
      cd22192
      Location:23630
      TRPV5-6; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6
      cd22296
      Location:642719
      CBD_TRPV5_C; C-terminal CaM binding domain found in transient receptor potential cation channel subfamily V member 5 (TRPV5) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      71503085..71531134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285403.1XP_063141473.1  transient receptor potential cation channel subfamily V member 5 isoform X1

      Related
      ENSRNOP00000046276.2, ENSRNOT00000051687.5