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    PRRC2B proline rich coiled-coil 2B [ Homo sapiens (human) ]

    Gene ID: 84726, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PRRC2Bprovided by HGNC
    Official Full Name
    proline rich coiled-coil 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:28121
    See related
    Ensembl:ENSG00000288701 MIM:619544; AllianceGenome:HGNC:28121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAT2L; BAT2L1; LQFBS-1; KIAA0515
    Summary
    Enables RNA binding activity. Predicted to be involved in cell differentiation. Predicted to act upstream of or within in utero embryonic development. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in brain (RPKM 18.3), ovary (RPKM 17.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRRC2B in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131373651..131500193)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143583138..143713087)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134249038..134375580)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134176375-134176876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134176877-134177376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20412 Neighboring gene phospholipid phosphatase 7 (inactive) Neighboring gene ReSE screen-validated silencer GRCh37_chr9:134197285-134197821 Neighboring gene uncharacterized LOC105376299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134205514-134206468 Neighboring gene uncharacterized LOC105376300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134227487-134227988 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134230857-134231474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134231475-134232090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134234556-134235172 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134248209-134248730 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134248731-134249254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134269973-134270734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:134271497-134272258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134276654-134277645 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134284252-134284752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29189 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134311463-134312438 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134312439-134313412 Neighboring gene Sharpr-MPRA regulatory region 9532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134364584-134365084 Neighboring gene small nucleolar RNA, C/D box 62A Neighboring gene uncharacterized LOC124902290 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134375403-134376602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378091-134378958 Neighboring gene small nucleolar RNA, C/D box 62B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378959-134379824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388206-134388706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388707-134389207 Neighboring gene uncharacterized LOC105376301 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134403902-134405101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134405807-134406720 Neighboring gene protein O-mannosyltransferase 1 Neighboring gene uridine-cytidine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression. Jiang F, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37125639, Free PMC Article
    2. Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis. Huang W, et al. Int J Chron Obstruct Pulmon Dis, 2024. PMID 38348310, Free PMC Article
    3. Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, et al. Genome Res, 2016 Sep. PMID 27365365, Free PMC Article
    4. EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway. Xie C, et al. Biomed Res Int, 2020. PMID 33029523, Free PMC Article
    5. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. Vasilescu J, et al. J Proteome Res, 2007 Jan. PMID 17203973

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis.
      Title: Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis.
    2. RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression.
      Title: RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0515, MGC10526, DKFZp781F05101, DKFZp781K12107

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC2B
    Names
    HLA-B associated transcript 2-like
    HLA-B-associated transcript 2-like 1
    proline-rich coiled-coil protein 2B
    protein BAT2-like 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384818.1 → NP_001371747.1  protein PRRC2B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Consensus CDS
      CCDS48044.1
      UniProtKB/Swiss-Prot
      O60270, Q5JSZ5, Q5JSZ7, Q66VZ2, Q68CR0, Q96EI9, Q9H683
      Related
      ENSP00000508005.1, ENST00000684596.1
      Conserved Domains (2) summary
      pfam03154
      Location:1866 → 2175
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    2. NM_001384821.1 → NP_001371750.1  protein PRRC2B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Conserved Domains (2) summary
      pfam03154
      Location:1865 → 2174
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    3. NM_001384822.1 → NP_001371751.1  protein PRRC2B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Conserved Domains (2) summary
      pfam03154
      Location:1865 → 2154
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    4. NM_001384823.1 → NP_001371752.1  protein PRRC2B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Related
      ENSP00000508073.1, ENST00000682501.1
      Conserved Domains (1) summary
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    5. NM_013318.4 → NP_037450.2  protein PRRC2B isoform 1

      See identical proteins and their annotated locations for NP_037450.2

      Status: VALIDATED

      Source sequence(s)
      AL354855, AL358781
      Consensus CDS
      CCDS48044.1
      UniProtKB/Swiss-Prot
      O60270, Q5JSZ5, Q5JSZ7, Q66VZ2, Q68CR0, Q96EI9, Q9H683
      Related
      ENSP00000508048.1, ENST00000683519.1
      Conserved Domains (2) summary
      pfam03154
      Location:1866 → 2175
      Atrophin-1; Atrophin-1 family
      pfam07001
      Location:1 → 189
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      131373651..131500193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      143583138..143713087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032640.2: Suppressed sequence

      Description
      NM_032640.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JSZ5.2 GenPept UniProtKB/Swiss-Prot:Q5JSZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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