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    Sgip1 SH3-domain GRB2-like (endophilin) interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 73094, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sgip1provided by MGI
    Official Full Name
    SH3-domain GRB2-like (endophilin) interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1920344
    See related
    Ensembl:ENSMUSG00000028524 AllianceGenome:MGI:1920344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gag; SGIP1alpha; 3110007P09Rik
    Summary
    Enables microtubule binding activity and phospholipid binding activity. Involved in positive regulation of receptor-mediated endocytosis and synaptic vesicle endocytosis. Located in clathrin-coated vesicle and plasma membrane. Part of AP-2 adaptor complex. Is active in presynapse. Is expressed in central nervous system; genitourinary system; and small intestine. Orthologous to human SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.0), cortex adult (RPKM 5.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sgip1 in Genome Data Viewer
    Location:
    4 C6; 4 47.09 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (102616351..102834623)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (102741302..102977426)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 4B, cAMP specific Neighboring gene STARR-positive B cell enhancer ABC_E4639 Neighboring gene STARR-positive B cell enhancer ABC_E1034 Neighboring gene STARR-seq mESC enhancer starr_10927 Neighboring gene predicted gene, 52667 Neighboring gene predicted gene, 24869 Neighboring gene STARR-seq mESC enhancer starr_10929 Neighboring gene STARR-seq mESC enhancer starr_10931 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102663627-102663912 Neighboring gene STARR-seq mESC enhancer starr_10932 Neighboring gene predicted gene 12709 Neighboring gene dynein light chain Tctex-type 5 Neighboring gene expressed sequence BB031773 Neighboring gene insulin-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB(1) receptors. Dvorakova M, et al. Br J Pharmacol, 2021 Apr. PMID 33491188, Free PMC Article
    2. SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner. Hájková A, et al. Neuropharmacology, 2016 Aug. PMID 26970018
    3. Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization. Durydivka O, et al. Gene, 2024 Jan 20. PMID 37783296
    4. SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses. Lee SE, et al. Mol Brain, 2019 May 3. PMID 31053155, Free PMC Article
    5. Enhanced clathrin-dependent endocytosis in the absence of calnexin. Li HD, et al. PLoS One, 2011. PMID 21747946, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization.
      Title: Multiple Sgip1 splice variants inhibit cannabinoid receptor 1 internalization.
    2. SGIP1alpha is an endocytic adaptor dedicated to the retrieval of surface-stranded Syt1.
      Title: SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses.
    3. Study showed that SGIP1 prevents the endocytosis of activated CB1R and that it alters signaling via the CB1R in a biased manner. CB1R mediated G-protein activation is selectively influenced by SGIP1, beta-arrestin associated signaling is changed profoundly, most likely as a consequence of the prevention of the receptor's internalization elicited by SGIP1.
      Title: SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner.
    4. SGIP1 is an important and novel member of the group of neuronal molecules required for the regulation of energy homeostasis
      Title: Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of eating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to dietary excess ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to dietary excess ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3-containing GRB2-like protein 3-interacting protein 1
    Names
    SH3-domain GRB2-like interacting protein 1 alpha
    endophilin-3-interacting protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285852.1 → NP_001272781.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK147926, AL732543, BY249204, BY617051
      UniProtKB/TrEMBL
      Q3UGH4
      Conserved Domains (1) summary
      cd09266
      Location:587 → 853
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    2. NM_001285859.1 → NP_001272788.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform c

      See identical proteins and their annotated locations for NP_001272788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK043018, AK147926, AL732543, BY249204, BY617051
      Consensus CDS
      CCDS71429.1
      UniProtKB/TrEMBL
      F7CPX0
      Related
      ENSMUSP00000063712.8, ENSMUST00000066824.14
      Conserved Domains (1) summary
      cd09266
      Location:392 → 658
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    3. NM_001285860.1 → NP_001272789.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region, and also lacks two alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AK032439, AK147926, AL732543, BY249204, BY617051
      Consensus CDS
      CCDS71430.1
      UniProtKB/TrEMBL
      F7CPX0
      Related
      ENSMUSP00000072301.6, ENSMUST00000072481.12
      Conserved Domains (1) summary
      cd09266
      Location:372 → 638
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    4. NM_001285862.1 → NP_001272791.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks six alternate in-frame exons among the 5' and central coding regions, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a.
      Source sequence(s)
      AK147926, AK148302, AL732543, BY249204, BY617051
      UniProtKB/TrEMBL
      F7CPX0
      Related
      ENSMUSP00000122556.2, ENSMUST00000149547.2
      Conserved Domains (1) summary
      cd09266
      Location:341 → 607
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    5. NM_144906.2 → NP_659155.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform b

      See identical proteins and their annotated locations for NP_659155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK147926, AL732543, BC017596, BY249204, BY617051
      Consensus CDS
      CCDS18404.1
      UniProtKB/Swiss-Prot
      A7BFW0, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q8VD37, Q9CXT2
      Related
      ENSMUSP00000079553.7, ENSMUST00000080728.13
      Conserved Domains (1) summary
      cd09266
      Location:539 → 805
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      102616351..102834623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164480.1 → XP_036020373.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X13

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (1) summary
      cd09266
      Location:364 → 630
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    2. XM_036164474.1 → XP_036020367.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1

      Conserved Domains (1) summary
      cd09266
      Location:589 → 855
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    3. XM_006503427.4 → XP_006503490.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X3

      Conserved Domains (1) summary
      cd09266
      Location:567 → 833
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    4. XM_036164475.1 → XP_036020368.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X2

      Conserved Domains (1) summary
      cd09266
      Location:581 → 847
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    5. XM_036164477.1 → XP_036020370.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (2) summary
      PHA03247
      Location:172 → 310
      PHA03247; large tegument protein UL36; Provisional
      cd09266
      Location:421 → 687
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    6. XM_017320403.2 → XP_017175892.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X8

      Conserved Domains (1) summary
      cd09266
      Location:401 → 667
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    7. XM_006503428.4 → XP_006503491.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q8VD37
      Related
      ENSMUSP00000102495.3, ENSMUST00000106882.9
      Conserved Domains (1) summary
      cd09266
      Location:559 → 825
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    8. XM_036164478.1 → XP_036020371.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X9

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (1) summary
      cd09266
      Location:387 → 653
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    9. XM_036164479.1 → XP_036020372.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X10

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (1) summary
      cd09266
      Location:385 → 651
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    10. XM_030253827.1 → XP_030109687.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X12

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (1) summary
      cd09266
      Location:365 → 631
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    11. XM_006503429.4 → XP_006503492.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X5

      Conserved Domains (1) summary
      cd09266
      Location:535 → 801
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    12. XM_036164476.1 → XP_036020369.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X6

      Conserved Domains (1) summary
      cd09266
      Location:515 → 781
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    13. XM_030253826.1 → XP_030109686.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X11

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (2) summary
      PHA03247
      Location:120 → 258
      PHA03247; large tegument protein UL36; Provisional
      cd09266
      Location:369 → 635
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    14. XM_036164481.1 → XP_036020374.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X14

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (1) summary
      cd09266
      Location:363 → 629
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    15. XM_036164482.1 → XP_036020375.1  SH3-containing GRB2-like protein 3-interacting protein 1 isoform X15

      UniProtKB/TrEMBL
      F7CPX0
      Conserved Domains (1) summary
      cd09266
      Location:361 → 627
      SGIP1_MHD; mu-homology domain (MHD) of Scr homology 3 (SH3)-domain growth factor receptor-bound 2 (GRB2)-like (endophilin) interacting protein 1 (also known as endophilin-3-interacting protein, SGIP1) and similar proteins

    RNA

    1. XR_004941969.1 RNA Sequence

    2. XR_004941975.1 RNA Sequence

    3. XR_004941978.1 RNA Sequence

    4. XR_004941984.1 RNA Sequence

    5. XR_004941977.1 RNA Sequence

    6. XR_004941979.1 RNA Sequence

    7. XR_004941970.1 RNA Sequence

    8. XR_004941976.1 RNA Sequence

    9. XR_004941980.1 RNA Sequence

    10. XR_004941987.1 RNA Sequence

    11. XR_004941972.1 RNA Sequence

    12. XR_376364.4 RNA Sequence

    13. XR_004941973.1 RNA Sequence

    14. XR_376362.4 RNA Sequence

    15. XR_004941982.1 RNA Sequence

    16. XR_376369.4 RNA Sequence

    17. XR_004941983.1 RNA Sequence

    18. XR_004941974.1 RNA Sequence

    19. XR_376370.4 RNA Sequence

    20. XR_004941971.1 RNA Sequence

    21. XR_004941985.1 RNA Sequence

    22. XR_004941989.1 RNA Sequence

    23. XR_004941990.1 RNA Sequence

    24. XR_004941981.1 RNA Sequence

    25. XR_004941986.1 RNA Sequence

    26. XR_003955027.1 RNA Sequence

    27. XR_004941988.1 RNA Sequence

    28. XR_004941991.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD37.1 GenPept UniProtKB/Swiss-Prot:Q8VD37

    Gene LinkOut

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