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    WASH2P WASP family homolog 2, pseudogene [ Homo sapiens (human) ]

    Gene ID: 375260, updated on 2-Nov-2024

    Summary

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    Official Symbol
    WASH2Pprovided by HGNC
    Official Full Name
    WASP family homolog 2, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:33145
    See related
    Ensembl:ENSG00000310523 AllianceGenome:HGNC:33145
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM39B
    Summary
    Predicted to enable alpha-tubulin binding activity and gamma-tubulin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; endosomal transport; and exocytosis. Predicted to be located in several cellular components, including autophagosome; centriole; and endosome. Predicted to be part of WASH complex. Predicted to be active in early endosome and recycling endosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 26.7), spleen (RPKM 25.8) and 25 other tissues See more
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    Genomic context

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    See WASH2P in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113583653..113599037)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (114008336..114023723)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (114341230..114356614)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:114334474-114334974 Neighboring gene uncharacterized LOC124907875 Neighboring gene family with sequence similarity 138 member B Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:114340974-114341805 Neighboring gene microRNA 1302-3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:114349651-114350508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:114354507-114355491 Neighboring gene uncharacterized LOC124907874 Neighboring gene DEAD/H-box helicase 11 like 2 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11884 Neighboring gene ribosomal protein L23a pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11885

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of the murine orthologue of a novel human subtelomeric multigene family. Gianfrancesco F, et al. Cytogenet Cell Genet, 2001. PMID 11701968
    2. Human subtelomeric WASH genes encode a new subclass of the WASP family. Linardopoulou EV, et al. PLoS Genet, 2007 Dec. PMID 18159949, Free PMC Article
    3. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. Ciccodicola A, et al. Hum Mol Genet, 2000 Feb 12. PMID 10655549
    4. Diverse fates of paralogs following segmental duplication of telomeric genes. Wong A, et al. Genomics, 2004 Aug. PMID 15233989
    5. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • WAS protein family homolog 2, pseudogene
    • family with sequence similarity 39, member B

    Clone Names

    • FLJ77647, FLJ98615, MGC52000, MGC90409, MGC104889, MGC111476, MGC117230, DKFZp434K1323

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024077.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL078621, BC073149, BX377099, BX537637, DA685507
      Related
      ENST00000692602.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      113583653..113599037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      114008336..114023723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198943.1: Suppressed sequence

      Description
      NM_198943.1: This RefSeq was temporarily suppressed because currently there is insufficient data to support this transcript and its predicted protein.
    Nucleotide Protein
    Heading Accession and Version

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