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    FMR1-AS1 FMR1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100126270, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FMR1-AS1provided by HGNC
    Official Full Name
    FMR1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:39081
    See related
    Ensembl:ENSG00000268066 MIM:300805; AllianceGenome:HGNC:39081
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FMR4; FMR5; ASFMR1; FMR1AS; FMR1-AS
    Summary
    Predicted to be involved in negative regulation of apoptotic process. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See FMR1-AS1 in Genome Data Viewer
    Location:
    Xq27.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (147909431..147911817, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (146174059..146176445, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (146990949..146993335, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 382, pseudogene Neighboring gene origin of replication upstream of FMR1 Neighboring gene uncharacterized LOC105373349 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:146965512-146965690 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:146980170-146980670 Neighboring gene origin of replication in 5' region of FMR1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30007 Neighboring gene fragile site, folic acid type, rare, fra(X)(q27.3) A Neighboring gene fragile X messenger ribonucleoprotein 1 Neighboring gene FMR1 neighbor Neighboring gene RNA, 5S ribosomal pseudogene 524

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. Peschansky VJ, et al. Mol Cell Neurosci, 2016 Jul. PMID 27001315
    2. De novo microduplication of the FMR1 gene in a patient with developmental delay, epilepsy and hyperactivity. Vengoechea J, et al. Eur J Hum Genet, 2012 Nov. PMID 22549406, Free PMC Article
    3. A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. Khalil AM, et al. PLoS One, 2008 Jan 23. PMID 18213394, Free PMC Article
    4. Correlation of FMR4 expression levels to ovarian reserve markers in FMR1 premutation carriers. Agusti I, et al. J Ovarian Res, 2024 May 17. PMID 38760837, Free PMC Article
    5. Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. Pastori C, et al. Hum Genet, 2014 Jan. PMID 24005575, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Correlation of FMR4 expression levels to ovarian reserve markers in FMR1 premutation carriers.
      Title: Correlation of FMR4 expression levels to ovarian reserve markers in FMR1 premutation carriers.
    2. Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NF-kappaB/c-Myc signaling in female esophageal carcinoma.
      Title: Exosomal FMR1-AS1 facilitates maintaining cancer stem-like cell dynamic equilibrium via TLR7/NFκB/c-Myc signaling in female esophageal carcinoma.
    3. FMR4 is a chromatin-associated transcript. FMR4 alters the chromatin state and the expression of several hundred genes in human neural precursor cells.
      Title: The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans.
    4. ASFMR1 may contribute to the variable phenotypes associated with the CGG repeat expansion.
      Title: An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • FMR1 antisense RNA 1 (head to head)
    • FMR1 antisense RNA 1 (non-protein coding)
    • antisense fragile X messenger ribonucleoprotein 1

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024499.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript.
      Source sequence(s)
      EU251065
      Related
      ENST00000601841.1

    2. NR_024501.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment compared to variant 1.
      Source sequence(s)
      EU251066
      Related
      ENST00000594922.5

    3. NR_024502.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal segments compared to variant 1.
      Source sequence(s)
      EU251067
      Related
      ENST00000596112.5

    4. NR_024503.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal segment compared to variant 1.
      Source sequence(s)
      EU251068
      Related
      ENST00000598667.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      147909431..147911817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      146174059..146176445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_024500.1: Suppressed sequence

      Description
      NR_024500.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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