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    Med20 mediator complex subunit 20 [ Mus musculus (house mouse) ]

    Gene ID: 56771, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Med20provided by MGI
    Official Full Name
    mediator complex subunit 20provided by MGI
    Primary source
    MGI:MGI:1929648
    See related
    Ensembl:ENSMUSG00000092558 AllianceGenome:MGI:1929648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trfp; 1110011O05Rik; 2410115I17Rik
    Summary
    Predicted to enable transcription coactivator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within skeletal muscle cell differentiation. Part of mediator complex. Is expressed in several structures, including early conceptus; eye; limb mesenchyme; oocyte; and tongue. Orthologous to human MED20 (mediator complex subunit 20). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 19.5), CNS E11.5 (RPKM 17.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med20 in Genome Data Viewer
    Location:
    17 C; 17 23.66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47922510..47935176)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47611585..47624251)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47679075-47679320 Neighboring gene predicted gene, 41590 Neighboring gene STARR-seq mESC enhancer starr_42717 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47732923-47733032 Neighboring gene STARR-positive B cell enhancer ABC_E9169 Neighboring gene bystin-like Neighboring gene predicted gene 20517 Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene ubiquitin specific peptidase 49 Neighboring gene prickle planar cell polarity protein 4 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene fibroblast growth factor receptor substrate 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MED20 is essential for early embryogenesis and regulates NANOG expression. Cui W, et al. Reproduction, 2019 Mar. PMID 30571656, Free PMC Article
    2. Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy. Weng L, et al. Nat Commun, 2024 Jan 2. PMID 38168040, Free PMC Article
    3. The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Tang WS, et al. Cell Rep, 2021 Jul 6. PMID 34233190
    4. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
    5. Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. Sato S, et al. J Biol Chem, 2003 Apr 25. PMID 12584197

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
      Title: The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Gm20517

    Readthrough gene: Gm20517, Included gene: Usp49

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 20
    Names
    Trf (TATA binding protein-related factor)-proximal protein homolog
    ubiquitin specific protease 49

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364926.1 → NP_001351855.1  mediator of RNA polymerase II transcription subunit 20 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK041624, AW048999, BC060122
      UniProtKB/TrEMBL
      G3UVU6
      Related
      ENSMUST00000138638.2
      Conserved Domains (1) summary
      pfam08612
      Location:1 → 142
      Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

    2. NM_001364927.1 → NP_001351856.1  mediator of RNA polymerase II transcription subunit 20 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139214
      Conserved Domains (1) summary
      pfam08612
      Location:1 → 136
      Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

    3. NM_020048.4 → NP_064432.1  mediator of RNA polymerase II transcription subunit 20 isoform 1

      See identical proteins and their annotated locations for NP_064432.1

      Status: VALIDATED

      Source sequence(s)
      AK041624, AK043396
      Consensus CDS
      CCDS28851.1
      UniProtKB/Swiss-Prot
      Q3UJQ7, Q3V418, Q6PAR6, Q9R0X0
      Related
      ENSMUSP00000024778.3, ENSMUST00000024778.3
      Conserved Domains (1) summary
      pfam08612
      Location:1 → 198
      Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

    RNA

    1. NR_157365.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK041624, AK043396, AW048999, DV065003

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47922510..47935176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0X0.1 GenPept UniProtKB/Swiss-Prot:Q9R0X0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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