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    Wdr89 WD repeat domain 89 [ Mus musculus (house mouse) ]

    Gene ID: 72338, updated on 12-May-2024

    Summary

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    Official Symbol
    Wdr89provided by MGI
    Official Full Name
    WD repeat domain 89provided by MGI
    Primary source
    MGI:MGI:1919588
    See related
    Ensembl:ENSMUSG00000045690 AllianceGenome:MGI:1919588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600001A11Rik
    Summary
    Orthologous to human WDR89 (WD repeat domain 89). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.8), liver E14 (RPKM 30.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wdr89 in Genome Data Viewer
    Location:
    12 C3; 12 32.89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (75677368..75716311, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (75630594..75669537, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:76550614-76550799 Neighboring gene STARR-seq mESC enhancer starr_32492 Neighboring gene protein phosphatase 2, regulatory subunit B', epsilon Neighboring gene STARR-seq mESC enhancer starr_32494 Neighboring gene STARR-seq mESC enhancer starr_32495 Neighboring gene STARR-positive B cell enhancer ABC_E2388 Neighboring gene predicted gene, 34666 Neighboring gene ribosomal protein lateral stalk subunit P2, pseudogene 1 Neighboring gene predicted gene, 40890 Neighboring gene sphingosine-1-phosphate phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Kannan M, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078390, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC67964

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 89

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028203.1 → NP_082479.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_082479.1

      Status: VALIDATED

      Source sequence(s)
      AC124742
      Consensus CDS
      CCDS49090.1
      UniProtKB/Swiss-Prot
      Q9D0R9
      Related
      ENSMUSP00000050532.8, ENSMUST00000062370.9
      Conserved Domains (3) summary
      COG2319
      Location:65 → 348
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:74 → 111
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:38 → 348
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      75677368..75716311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0R9.1 GenPept UniProtKB/Swiss-Prot:Q9D0R9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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