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    CYB5 Cyb5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855612, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CYB5
    Official Full Name
    Cyb5p
    Primary source
    SGD:S000005055
    Locus tag
    YNL111C
    See related
    AllianceGenome:SGD:S000005055; FungiDB:YNL111C; VEuPathDB:YNL111C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables electron transfer activity. Involved in sterol biosynthetic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to several human genes including CYB5A (cytochrome b5 type A). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CYB5 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (416940..417302, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase core subunit RPC19 Neighboring gene DEAD-box ATP-dependent RNA helicase DBP2 Neighboring gene rRNA-binding ribosome biosynthesis protein NOP15 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of intact cytochrome b5 from yeast microsomes. Yoshida Y, et al. Arch Biochem Biophys, 1983 Feb 1. PMID 6337556
    2. Improvement of polyunsaturated fatty acids synthesis by the coexpression of CYB5 with desaturase genes in Saccharomyces cerevisiae. Yazawa H, et al. Appl Microbiol Biotechnol, 2010 Aug. PMID 20512324
    3. Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Truan G, et al. Gene, 1994 May 3. PMID 8181746
    4. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. Lamb DC, et al. FEBS Lett, 1999 Dec 3. PMID 10622712
    5. The DNA sequence of cosmid 14-13b from chromosome XIV of Saccharomyces cerevisiae reveals an unusually high number of overlapping open reading frames. De Antoni A, et al. Yeast, 1997 Mar 15. PMID 9090055

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cyb5p
    NP_014288.3
    • Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      416940..417302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182949.3 → NP_014288.3  TPA: Cyb5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014288.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W170, P40312
      UniProtKB/TrEMBL
      A6ZRX1, B3LNW8, C7GKD3, C8ZGB9, G2WLZ5, N1NXW5
      Conserved Domains (1) summary
      COG5274
      Location:1 → 119
      CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40312.2

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