BIVM basic, immunoglobulin-like variable motif containing [Homo sapiens (human)] - Gene

Summary

Official Symbol: BIVMprovided by HGNC
Official Full Name: basic, immunoglobulin-like variable motif containingprovided by HGNC
Primary source: HGNC:HGNC:16034
See related: Ensembl:ENSG00000134897 MIM:619006; AllianceGenome:HGNC:16034
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Located in extracellular space. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney (RPKM 9.2), heart (RPKM 8.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q33.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (102799119..102841533)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (102017295..102059729)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (103451469..103493883)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of genetic susceptibility in preterm newborns with bronchopulmonary dysplasia by whole-exome sequencing: BIVM gene may play a role.
Title: Identification of genetic susceptibility in preterm newborns with bronchopulmonary dysplasia by whole-exome sequencing: BIVM gene may play a role.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482343

D13S1028 (e-PCR)
- UniSTS:152361

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

RH66234 (e-PCR)
- UniSTS:37776

RH46417 (e-PCR)
- UniSTS:37271

WI-5740 (e-PCR)
- UniSTS:66256

Readthrough BIVM-ERCC5

Readthrough gene: BIVM-ERCC5, Included gene: ERCC5

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: basic immunoglobulin-like variable motif-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159596.2 → NP_001153068.1 basic immunoglobulin-like variable motif-containing protein isoform b

See identical proteins and their annotated locations for NP_001153068.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform b) is shorter than isoform a.

Source sequence(s)

AF411385, BC112339, GD145579

Consensus CDS

CCDS53879.1

UniProtKB/TrEMBL

A0A494C1A7

Related

ENSP00000412794.2, ENST00000448849.3
NM_017693.4 → NP_060163.2 basic immunoglobulin-like variable motif-containing protein isoform a

See identical proteins and their annotated locations for NP_060163.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AF411385, GD145579

Consensus CDS

CCDS9505.1

UniProtKB/Swiss-Prot

Q2M1J2, Q86UB2, Q9NXM4

UniProtKB/TrEMBL

A0A494C0D0

Related

ENSP00000257336.1, ENST00000257336.6