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    IGF2-AS IGF2 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 51214, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IGF2-ASprovided by HGNC
    Official Full Name
    IGF2 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:14062
    See related
    Ensembl:ENSG00000099869 MIM:610146; AllianceGenome:HGNC:14062
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PEG8; IGF2AS; IGF2-AS1
    Summary
    This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in placenta (RPKM 5.4), liver (RPKM 4.4) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IGF2-AS in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (2140512..2148666)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (2228165..2236316)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2161742..2169896)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2018584-2019431 Neighboring gene H19/IGF2 imprinting control region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2034666-2035394 Neighboring gene microRNA 675 Neighboring gene H19 imprinted maternally expressed transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2118490-2119132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2121061-2121703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2121704-2122345 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:2135598-2135868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2148496-2149320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2155593-2156179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2158413-2159034 Neighboring gene INS-IGF2 readthrough Neighboring gene microRNA 483 Neighboring gene insulin like growth factor 2 Neighboring gene insulin repeat instability region Neighboring gene insulin Neighboring gene tyrosine hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p/IGF2 axis and activating PI3K/AKT/mTOR signaling pathway. Jin X, et al. J Assist Reprod Genet, 2022 Dec. PMID 36508036, Free PMC Article
    2. Downregulation of lncRNA IGF2-AS-encoded peptide induces trophoblast - cycle arrest. Wu AH, et al. Reprod Biomed Online, 2021 Oct. PMID 34474977
    3. Long Non-Coding RNA IGF2AS in Serum may be a Biomarker for Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma. Qi J, et al. Clin Lab, 2019 Dec 1. PMID 31850718
    4. Long noncoding RNA IGF2AS regulates high-glucose induced apoptosis in human retinal pigment epithelial cells. Yu X, et al. IUBMB Life, 2019 Oct. PMID 31317640
    5. Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. Cao Y, et al. J Natl Cancer Inst, 2014 Jun. PMID 24824313, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p/IGF2 axis and activating PI3K/AKT/mTOR signaling pathway.
      Title: LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p/IGF2 axis and activating PI3K/AKT/mTOR signaling pathway.
    2. lncRNA IGF2-AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-3,126-5p to upregulate KLK4.
      Title: lncRNA IGF2-AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-3,126-5p to upregulate KLK4.
    3. Downregulation of lncRNA IGF2-AS-encoded peptide induces trophoblast - cycle arrest.
      Title: Downregulation of lncRNA IGF2-AS-encoded peptide induces trophoblast - cycle arrest.
    4. Over-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway.
      Title: Over-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway.
    5. Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.
      Title: Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.
    6. Long non-coding RNA IGF2-AS promotes trophoblast cell proliferation, migration, and invasion by regulating miR-520g/N-cadherin axis.
      Title: Long non-coding RNA IGF2-AS promotes trophoblast cell proliferation, migration, and invasion by regulating miR-520g/N-cadherin axis.
    7. IGF2-AS takes important regulatory parts in the gastric adenocarcinoma development by regulating SHOX2 via sponging miR-503.IGF2-AS is up-regulated in gastric adenocarcinoma tissues and correlated with poor prognosis.
      Title: IGF2-AS affects the prognosis and metastasis of gastric adenocarcinoma via acting as a ceRNA of miR-503 to regulate SHOX2.
    8. Data suggest that serum long non-coding RNA IGF2-AS (IGF2AS) may be a potential biomarker for the diagnosis of HBV-related hepatocellular carcinoma (HCC).
      Title: Long Non-Coding RNA IGF2AS in Serum may be a Biomarker for Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
    9. We demonstrated that inhibiting IGF2-AS, possibly also through activation of AKT signaling pathway, has a protective function in high-glucose-induced apoptosis in human retinal pigment epithelial cells in diabetic retinopathy.
      Title: Long noncoding RNA IGF2AS regulates high-glucose induced apoptosis in human retinal pigment epithelial cells.
    10. Germline variations in IGF2-AS gene were associated with prostate cancer mortality, independent of stage and Gleason score and specific to prostate cancer.
      Title: Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
    EBI GWAS Catalog
    Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
    EBI GWAS Catalog
    Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • IGF2 antisense RNA 1 (non-protein coding)
    • PEG8/IGF2AS, imprinting
    • insulin-like growth factor 2 antisense 1 (non-protein coding)
    • insulin-like growth factor II, antisense

    Clone Names

    • MGC168198

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028043.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript.
      Source sequence(s)
      AC132217, AL530868, BC136585, BC142634
      Related
      ENST00000381361.4

    2. NR_133657.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site resulting in a shorter transcript compared to variant 2.
      Source sequence(s)
      AC132217, AL530868, BC136585, BC142634
      Related
      ENST00000445504.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      2140512..2148666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      2228165..2236316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016412.2: Suppressed sequence

      Description
      NM_016412.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    2. NR_028044.1: Suppressed sequence

      Description
      NR_028044.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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