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    Fgd6 FYVE, RhoGEF and PH domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 13998, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fgd6provided by MGI
    Official Full Name
    FYVE, RhoGEF and PH domain containing 6provided by MGI
    Primary source
    MGI:MGI:1261419
    See related
    Ensembl:ENSMUSG00000020021 AllianceGenome:MGI:1261419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Etohd4; ZFYVE24
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in cerebral cortex. Orthologous to human FGD6 (FYVE, RhoGEF and PH domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.7), placenta adult (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fgd6 in Genome Data Viewer
    Location:
    10 C2; 10 48.76 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93871862..93981201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (94035979..94145339)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene STARR-positive B cell enhancer ABC_E1811 Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene Neighboring gene B-cell CLL/lymphoma 9-like pseudogene Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93661580-93661763 Neighboring gene predicted gene, 26122 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts. Steenblock C, et al. J Biol Chem, 2014 Jun 27. PMID 24821726, Free PMC Article
    2. Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst. Rout UK, et al. Cell Calcium, 1997 Dec. PMID 9502196
    3. The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Vezzali R, et al. Oncotarget, 2016 Jun 21. PMID 27224923, Free PMC Article
    4. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
    5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.
      Title: The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 6
    Names
    ethanol decreased 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053072.3 → NP_444302.4  FYVE, RhoGEF and PH domain-containing protein 6

      See identical proteins and their annotated locations for NP_444302.4

      Status: VALIDATED

      Source sequence(s)
      AK044341, AK173157, BF464747
      Consensus CDS
      CCDS48674.1
      UniProtKB/Swiss-Prot
      Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7
      UniProtKB/TrEMBL
      B2RSV7
      Related
      ENSMUSP00000020208.5, ENSMUST00000020208.5
      Conserved Domains (5) summary
      cd13237
      Location:1305 → 1393
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      cd15793
      Location:1047 → 1169
      PH1_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 6, N-terminal Pleckstrin Homology (PH) domain
      cd15743
      Location:1186 → 1246
      FYVE_FGD6; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar proteins
      pfam00169
      Location:1304 → 1395
      PH; PH domain
      pfam00621
      Location:845 → 1029
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93871862..93981201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155591.1 → XP_036011484.1  FYVE, RhoGEF and PH domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      B2RSV7
      Conserved Domains (4) summary
      cd13237
      Location:1307 → 1395
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      cd15743
      Location:1188 → 1248
      FYVE_FGD6; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar proteins
      pfam00621
      Location:845 → 1028
      RhoGEF; RhoGEF domain
      cl17171
      Location:1047 → 1171
      PH-like; Pleckstrin homology-like domain

    2. XM_036155592.1 → XP_036011485.1  FYVE, RhoGEF and PH domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      B2RSV7
      Conserved Domains (4) summary
      cd13237
      Location:1259 → 1347
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      cl28890
      Location:1168 → 1200
      FYVE_like_SF; FYVE domain like superfamily
      pfam00621
      Location:845 → 1028
      RhoGEF; RhoGEF domain
      cl17171
      Location:1047 → 1171
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_004936096.1 RNA Sequence

    2. XR_004936097.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZL1.2 GenPept UniProtKB/Swiss-Prot:Q69ZL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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