Cep83 centrosomal protein 83 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep83provided by MGI
Official Full Name: centrosomal protein 83provided by MGI
Primary source: MGI:MGI:1924298
See related: Ensembl:ENSMUSG00000020024 AllianceGenome:MGI:1924298
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccdc41; 2600001G24Rik; 4921537D05Rik; 5730513H21Rik
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within cilium assembly and establishment of centrosome localization. Located in centriole. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in nephronophthisis 18. Orthologous to human CEP83 (centrosomal protein 83). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 7.1), CNS E11.5 (RPKM 6.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C2; 10 49.05 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (94524476..94626201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (94688624..94790336)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

4921537D05Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	IEA Inferred from Electronic Annotation more info
involved_in vesicle docking	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of ciliary transition fiber	IBA Inferred from Biological aspect of Ancestor more info
part_of ciliary transition fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 83 kDa

Names: coiled-coil domain containing 41; coiled-coil domain-containing protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029852.2 → NP_084128.2 centrosomal protein of 83 kDa

See identical proteins and their annotated locations for NP_084128.2

Status: VALIDATED

Source sequence(s)

BC070464

Consensus CDS

CCDS36041.1

UniProtKB/Swiss-Prot

Q3U7X7, Q3UX57, Q80VF0, Q9D5R3

Related

ENSMUSP00000020212.5, ENSMUST00000020212.6

Conserved Domains (1) summary

COG1196
Location:39 → 622

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]