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    Cdc7 cell division cycle 7 [ Mus musculus (house mouse) ]

    Gene ID: 12545, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdc7provided by MGI
    Official Full Name
    cell division cycle 7provided by MGI
    Primary source
    MGI:MGI:1309511
    See related
    Ensembl:ENSMUSG00000029283 AllianceGenome:MGI:1309511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc7l1; muCdc7
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cell cycle phase transition; double-strand break repair via break-induced replication; and positive regulation of cell cycle process. Predicted to be located in intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; hemolymphoid system gland; musculature; nervous system; and sensory organ. Orthologous to human CDC7 (cell division cycle 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 17.6), limb E14.5 (RPKM 17.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc7 in Genome Data Viewer
    Location:
    5 E5; 5 51.43 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107112201..107132298)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (106964315..106984440)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33327 Neighboring gene STARR-seq mESC enhancer starr_13877 Neighboring gene HFM1, ATP-dependent DNA helicase homolog Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:107320773-107320956 Neighboring gene STARR-positive B cell enhancer ABC_E4773 Neighboring gene STARR-seq mESC enhancer starr_13878 Neighboring gene olfactory receptor 719, pseudogene Neighboring gene STARR-seq mESC enhancer starr_13879 Neighboring gene STARR-seq mESC enhancer starr_13880 Neighboring gene STARR-seq mESC enhancer starr_13882 Neighboring gene predicted gene, 33371 Neighboring gene predicted gene, 33474

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CDC7-independent G1/S transition revealed by targeted protein degradation. Suski JM, et al. Nature, 2022 May. PMID 35508654, Free PMC Article
    2. Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for s. cerevisiae Cdc7-related kinase. Kim JM, et al. J Biol Chem, 1998 Sep 4. PMID 9722556
    3. Identification and characterization of mouse homologue to yeast Cdc7 protein and chromosomal localization of the cognate mouse gene Cdc7l. Faul T, et al. Chromosoma, 1999 Apr. PMID 10199953
    4. Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis. Kim JM, et al. EMBO J, 2003 Oct 1. PMID 14517263, Free PMC Article
    5. Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination. Gondo Y, et al. Biochem Biophys Res Commun, 1994 Jul 29. PMID 8048955

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cdc7 kinase is required for postnatal brain development.
      Title: Cdc7 kinase is required for postnatal brain development.
    2. CDC7-independent G1/S transition revealed by targeted protein degradation.
      Title: CDC7-independent G1/S transition revealed by targeted protein degradation.
    3. Results suggest a new role of Claspin in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins.
      Title: Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.
    4. Increased Cdc7-dependent replication initiation is a hallmark of p53 gain-of function mutations in lung adenocarcinoma.
      Title: p53 gain-of-function mutations increase Cdc7-dependent replication initiation.
    5. Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity
      Title: Cell division cycle 7 mediates transforming growth factor-β-induced smooth muscle maturation through activation of myocardin gene transcription.
    6. Cdc7 mediates SMC differentiation through a mechanism distinct from cell proliferation.
      Title: Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation.
    7. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin
      Title: Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91067

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear cell cycle DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nuclear cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle 7-related protein kinase
    Names
    CDC7-related kinase
    cell division cycle 7-like 1
    NP_001258495.1
    NP_001258496.1
    NP_001258497.1
    NP_001407653.1
    NP_001407654.1
    NP_001407655.1
    NP_033993.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271566.2 → NP_001258495.1  cell division cycle 7-related protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001258495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC134409
      Consensus CDS
      CCDS19498.1
      UniProtKB/Swiss-Prot
      Q9WUV1, Q9Z0H0, Q9Z2Y7
      Related
      ENSMUSP00000113385.2, ENSMUST00000118261.8
      Conserved Domains (2) summary
      cd14019
      Location:50 → 429
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:337 → 559
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001271567.2 → NP_001258496.1  cell division cycle 7-related protein kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform (1).
      Source sequence(s)
      AC134409
      Consensus CDS
      CCDS71628.1
      UniProtKB/Swiss-Prot
      Q9Z0H0
      Related
      ENSMUSP00000112392.3, ENSMUST00000117196.9
      Conserved Domains (2) summary
      cd14019
      Location:50 → 397
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:305 → 527
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001271568.2 → NP_001258497.1  cell division cycle 7-related protein kinase isoform 3

      See identical proteins and their annotated locations for NP_001258497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks an alternate in-frame exon and uses an alternate in-frame acceptor splice site in the coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform (1).
      Source sequence(s)
      AC134409
      Consensus CDS
      CCDS71629.1
      UniProtKB/TrEMBL
      Q66JY4
      Related
      ENSMUSP00000075792.7, ENSMUST00000076467.13
      Conserved Domains (1) summary
      cd14019
      Location:50 → 390
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase

    4. NM_001420724.1 → NP_001407653.1  cell division cycle 7-related protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134409

    5. NM_001420725.1 → NP_001407654.1  cell division cycle 7-related protein kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134409

    6. NM_001420726.1 → NP_001407655.1  cell division cycle 7-related protein kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC134409

    7. NM_009863.4 → NP_033993.2  cell division cycle 7-related protein kinase isoform 1

      See identical proteins and their annotated locations for NP_033993.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC134409
      Consensus CDS
      CCDS19498.1
      UniProtKB/Swiss-Prot
      Q9WUV1, Q9Z0H0, Q9Z2Y7
      Related
      ENSMUSP00000031221.6, ENSMUST00000031221.12
      Conserved Domains (2) summary
      cd14019
      Location:50 → 429
      STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
      cl21453
      Location:337 → 559
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107112201..107132298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0H0.2 GenPept UniProtKB/Swiss-Prot:Q9Z0H0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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