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    BTNL3 butyrophilin like 3 [ Homo sapiens (human) ]

    Gene ID: 10917, updated on 2-Nov-2024

    Summary

    Official Symbol
    BTNL3provided by HGNC
    Official Full Name
    butyrophilin like 3provided by HGNC
    Primary source
    HGNC:HGNC:1143
    See related
    Ensembl:ENSG00000168903 MIM:606192; AllianceGenome:HGNC:1143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTNLR; BTN9.1
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum (RPKM 59.3), small intestine (RPKM 43.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See BTNL3 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180988846..181006727)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181545217..181563111)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180415846..180433727)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene TERF2 interacting protein pseudogene Neighboring gene TMEM69 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23774 Neighboring gene ARPP19 pseudogene 1 Neighboring gene RNA, U6 small nuclear 1036, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180463160-180463538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180463783-180464709 Neighboring gene butyrophilin like 9 Neighboring gene microRNA 8089

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function  
    enables protein binding PubMed 
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway  
    involved_in biological_process  
    involved_in regulation of cytokine production  
    Component Evidence Code Pubs
    is_active_in cellular_component  
    is_active_in external side of plasma membrane  

    General protein information

    Preferred Names
    butyrophilin-like protein 3
    Names
    butyrophilin-like receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_197975.3NP_932079.1  butyrophilin-like protein 3 precursor

      See identical proteins and their annotated locations for NP_932079.1

      Status: VALIDATED

      Source sequence(s)
      AK025267, AY358385, DA431389
      Consensus CDS
      CCDS47358.1
      UniProtKB/Swiss-Prot
      Q496L7, Q6UXE8, Q9Y2C7
      Related
      ENSP00000341787.6, ENST00000342868.7
      Conserved Domains (2) summary
      cd13733
      Location:289461
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cd05713
      Location:33132
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      180988846..181006727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      181545217..181563111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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