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    TECTA tectorin alpha [ Homo sapiens (human) ]

    Gene ID: 7007, updated on 28-Oct-2024

    Summary

    Official Symbol
    TECTAprovided by HGNC
    Official Full Name
    tectorin alphaprovided by HGNC
    Primary source
    HGNC:HGNC:11720
    See related
    Ensembl:ENSG00000109927 MIM:602574; AllianceGenome:HGNC:11720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DFNA8; DFNA12; DFNB21
    Summary
    The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 1.1), testis (RPKM 0.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TECTA in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (121101243..121191490)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (121124974..121216595)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120971952..121062199)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 4 Neighboring gene uncharacterized LOC101929208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120826209-120826709 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120829234-120829455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3997 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3999 Neighboring gene TBCEL-TECTA readthrough Neighboring gene HNF4 motif-containing MPRA enhancer 256 Neighboring gene tubulin folding cofactor E like Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:121000154-121001353 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:121083583-121084082 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:121106857-121107396 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:121107397-121107936 Neighboring gene uncharacterized LOC105369533 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:121107937-121108476 Neighboring gene NANOG hESC enhancer GRCh37_chr11:121110682-121111230 Neighboring gene uncharacterized LOC105369534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:121117070-121117656 Neighboring gene TRPC6 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough TBCEL-TECTA

    Readthrough gene: TBCEL-TECTA, Included gene: TBCEL

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in auditory receptor cell stereocilium organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011633.1 RefSeqGene

      Range
      3578..93825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005422.4NP_005413.2  alpha-tectorin precursor

      See identical proteins and their annotated locations for NP_005413.2

      Status: REVIEWED

      Source sequence(s)
      AP000646, AP000826
      Consensus CDS
      CCDS8434.1
      UniProtKB/Swiss-Prot
      O75443
      UniProtKB/TrEMBL
      A0A2R8YDL0
      Related
      ENSP00000376543.1, ENST00000392793.6
      Conserved Domains (10) summary
      smart00216
      Location:703865
      VWD; von Willebrand factor (vWF) type D domain
      smart00241
      Location:18052057
      ZP; Zona pellucida (ZP) domain
      smart00539
      Location:98254
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00832
      Location:517591
      C8; This domain contains 8 conserved cysteine residues
      pfam00094
      Location:322478
      VWD; von Willebrand factor type D domain
      pfam00100
      Location:19372057
      Zona_pellucida; Zona pellucida-like domain
      pfam01826
      Location:597650
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:12981368
      C8; C8 domain
      pfam14670
      Location:20892121
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl17735
      Location:652706
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      121101243..121191490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      121124974..121216595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)