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    UBE2R2 ubiquitin conjugating enzyme E2 R2 [ Homo sapiens (human) ]

    Gene ID: 54926, updated on 28-Oct-2024

    Summary

    Official Symbol
    UBE2R2provided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 R2provided by HGNC
    Primary source
    HGNC:HGNC:19907
    See related
    Ensembl:ENSG00000107341 MIM:612506; AllianceGenome:HGNC:19907
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC3B; CDC34B; E2-CDC34B
    Summary
    Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 25.6), endometrium (RPKM 16.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBE2R2 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33815168..33920399)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33835748..33938999)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33817158..33920397)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33721507-33722008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33722009-33722508 Neighboring gene UBE2R2 antisense RNA 1 Neighboring gene MPRA-validated peak7221 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28301 Neighboring gene serine protease 3 Neighboring gene T cell receptor beta variable 29/OR9-2 (non-functional) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33796108-33796608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19839 Neighboring gene RNA, U4atac small nuclear 11, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33927431-33928421 Neighboring gene small nucleolar RNA, C/D box 121B Neighboring gene ubiquitin associated protein 2 Neighboring gene small nucleolar RNA, C/D box 121A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20419, MGC10481

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 R2
    Names
    E2 ubiquitin-conjugating enzyme R2
    ubiquitin carrier protein R2
    ubiquitin conjugating enzyme E2R 2
    ubiquitin-conjugating enzyme E2-CDC34B
    ubiquitin-conjugating enzyme UBC3B
    ubiquitin-protein ligase R2
    NP_060281.2
    XP_005251553.1
    XP_011516251.1
    XP_016870349.1
    XP_047279497.1
    XP_054219154.1
    XP_054219155.1
    XP_054219156.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017811.4NP_060281.2  ubiquitin-conjugating enzyme E2 R2

      See identical proteins and their annotated locations for NP_060281.2

      Status: REVIEWED

      Source sequence(s)
      AA397839, AK000426, AL133827, AL139113, AW966809, BC004862, BC047584, BI061548, BI908167, BQ432410, CD515389, CN310827, CN427315
      Consensus CDS
      CCDS6546.1
      UniProtKB/Swiss-Prot
      D3DRL5, Q712K3, Q9NX64
      Related
      ENSP00000263228.3, ENST00000263228.4
      Conserved Domains (1) summary
      cd00195
      Location:11169
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33815168..33920399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423541.1XP_047279497.1  ubiquitin-conjugating enzyme E2 R2 isoform X4

    2. XM_011517949.2XP_011516251.1  ubiquitin-conjugating enzyme E2 R2 isoform X2

      See identical proteins and their annotated locations for XP_011516251.1

      Conserved Domains (1) summary
      cd00195
      Location:11122
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. XM_005251496.3XP_005251553.1  ubiquitin-conjugating enzyme E2 R2 isoform X1

      See identical proteins and their annotated locations for XP_005251553.1

      Conserved Domains (1) summary
      cd00195
      Location:11140
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    4. XM_017014860.2XP_016870349.1  ubiquitin-conjugating enzyme E2 R2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33835748..33938999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363180.1XP_054219155.1  ubiquitin-conjugating enzyme E2 R2 isoform X2

    2. XM_054363179.1XP_054219154.1  ubiquitin-conjugating enzyme E2 R2 isoform X1

    3. XM_054363181.1XP_054219156.1  ubiquitin-conjugating enzyme E2 R2 isoform X3