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    FCGRT Fc gamma receptor and transporter [ Homo sapiens (human) ]

    Gene ID: 2217, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FCGRTprovided by HGNC
    Official Full Name
    Fc gamma receptor and transporterprovided by HGNC
    Primary source
    HGNC:HGNC:3621
    See related
    Ensembl:ENSG00000104870 MIM:601437; AllianceGenome:HGNC:3621
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCRN; FcgammaRn; alpha-chain
    Summary
    This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    Expression
    Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCGRT in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49512661..49526428)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52512666..52526423)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50015918..50029685)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50003846-50004617 Neighboring gene Sharpr-MPRA regulatory region 15417 Neighboring gene microRNA 150 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50014938-50015500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50017428-50018141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50031176-50031754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10920 Neighboring gene reticulocalbin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50059309-50060090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14948 Neighboring gene nitric oxide synthase interacting protein Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50070496-50070674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kinetics of FcRn-mediated recycling of IgG and albumin in human: pathophysiology and therapeutic implications using a simplified mechanism-based model. Kim J, et al. Clin Immunol, 2007 Feb. PMID 17046328, Free PMC Article
    2. Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies. Schlothauer T, et al. MAbs, 2013 Jul-Aug. PMID 23765230, Free PMC Article
    3. Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity? Gurbaxani B, et al. Mol Immunol, 2013 Dec. PMID 23917469
    4. Binding structures and energies of the human neonatal Fc receptor with human Fc and its mutants by molecular modeling and dynamics simulations. Huang X, et al. Mol Biosyst, 2013 Dec. PMID 24057047, Free PMC Article
    5. Human and non-human primate intestinal FcRn expression and immunoglobulin G transcytosis. Hornby PJ, et al. Pharm Res, 2014 Apr. PMID 24072267, Free PMC Article

    See all (144) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of immunoglobulin transport receptor, neonatal Fc receptor in mucosal infection and immunity and therapeutic intervention.
      Title: The role of immunoglobulin transport receptor, neonatal Fc receptor in mucosal infection and immunity and therapeutic intervention.
    2. Albumin influences leucocyte FcRn expression in the early days of kidney transplantation.
      Title: Albumin influences leucocyte FcRn expression in the early days of kidney transplantation.
    3. Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy.
      Title: Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy.
    4. The therapeutic age of the neonatal Fc receptor.
      Title: The therapeutic age of the neonatal Fc receptor.
    5. Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
      Title: Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
    6. Human IgE does not bind to human FcRn.
      Title: Human IgE does not bind to human FcRn.
    7. An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
      Title: An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.
    8. Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus.
      Title: Neonatal Fc receptor expression in lymphoid and myeloid cells in systemic lupus erythematosus.
    9. Research progress on neonatal Fc receptor and its application.
      Title: Research progress on neonatal Fc receptor and its application.
    10. Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.
      Title: Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice.
    Submit: New GeneRIF Correction See all GeneRIFs (109)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-2-microglobulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables peptide antigen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    IgG receptor FcRn large subunit p51
    Names
    Fc fragment of IgG receptor and transporter
    Fc fragment of IgG, receptor, transporter, alpha
    FcRn alpha chain
    IgG Fc fragment receptor transporter alpha chain
    heavy chain of the major histocompatibility complex class I-like Fc receptor
    immunoglobulin receptor, intestinal, heavy chain
    major histocompatibility complex class I-like Fc receptor
    neonatal Fc receptor
    neonatal Fc-receptor for Ig
    neonatal fragment crystallizable Fc receptor FcRn
    transmembrane alpha chain of the neonatal receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136019.3 → NP_001129491.1  IgG receptor FcRn large subunit p51 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001129491.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC010619, BC091487, BE245284
      Consensus CDS
      CCDS12770.1
      UniProtKB/Swiss-Prot
      P55899, Q5HYM5, Q9HBV7, Q9NZ19
      UniProtKB/TrEMBL
      A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1
      Related
      ENSP00000221466.4, ENST00000221466.10
      Conserved Domains (2) summary
      cd21011
      Location:198 → 290
      IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
      cl08246
      Location:25 → 197
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. NM_001411064.1 → NP_001397993.1  IgG receptor FcRn large subunit p51 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR, compared to variant 1 and skips an internal exon. It encodes a shorter protein (2), compared to isoform 1.
      Source sequence(s)
      AC010619
      Consensus CDS
      CCDS92663.1
      UniProtKB/TrEMBL
      M0R0A9
      Related
      ENSP00000471118.1, ENST00000596975.5

    3. NM_004107.5 → NP_004098.1  IgG receptor FcRn large subunit p51 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004098.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      BC008734, BE245284
      Consensus CDS
      CCDS12770.1
      UniProtKB/Swiss-Prot
      P55899, Q5HYM5, Q9HBV7, Q9NZ19
      UniProtKB/TrEMBL
      A0A024QZI2, A0A1W6R2Y2, A0A1W6R2Z1
      Related
      ENSP00000410798.2, ENST00000426395.7
      Conserved Domains (2) summary
      cd21011
      Location:198 → 290
      IgC1_MHC-like_FcRn; immunoglobulin domain of neonatal Fc receptor, major histocompatibility complex (MHC)-like; member of the C1-set of Ig superfamily (IgSF) domains
      cl08246
      Location:25 → 197
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49512661..49526428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438411.1 → XP_047294367.1  IgG receptor FcRn large subunit p51 isoform X3

    2. XM_047438408.1 → XP_047294364.1  IgG receptor FcRn large subunit p51 isoform X1

    3. XM_047438410.1 → XP_047294366.1  IgG receptor FcRn large subunit p51 isoform X2

    4. XM_047438412.1 → XP_047294368.1  IgG receptor FcRn large subunit p51 isoform X4

      Related
      ENSP00000469933.1, ENST00000600273.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52512666..52526423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320202.1 → XP_054176177.1  IgG receptor FcRn large subunit p51 isoform X3

    2. XM_054320200.1 → XP_054176175.1  IgG receptor FcRn large subunit p51 isoform X1

    3. XM_054320201.1 → XP_054176176.1  IgG receptor FcRn large subunit p51 isoform X2

    4. XM_054320203.1 → XP_054176178.1  IgG receptor FcRn large subunit p51 isoform X4

    5. XM_054320199.1 → XP_054176174.1  IgG receptor FcRn large subunit p51 isoform X5

      UniProtKB/Swiss-Prot
      P55899, Q5HYM5, Q9HBV7, Q9NZ19
      UniProtKB/TrEMBL
      A0A024QZI2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55899.1 GenPept UniProtKB/Swiss-Prot:P55899

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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