Zfp292 zinc finger protein 292 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp292provided by MGI
Official Full Name: zinc finger protein 292provided by MGI
Primary source: MGI:MGI:1353423
See related: Ensembl:ENSMUSG00000039967 AllianceGenome:MGI:1353423
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfp15; Zn-15; Zn-16; Zfp-15; Krox-10; mKIAA0530; 5730450D02Rik; 5830493J20Rik; 9430062L07Rik
Summary: Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human ZNF292 (zinc finger protein 292). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 6.0), CNS E14 (RPKM 5.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 16.86 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (34803110..34882982, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (34803110..34882983, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that long noncoding RNA Kdm2b expression sustains the maintenance of Innate lymphoid cells by promoting their proliferation through activation of the transcription factor Zfp292
Title: Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression.
first in vivo evidence that Zn-16 mRNA abundance correlates with growth hormone expression
Title: Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI449016 (e-PCR)
- UniSTS:178979

NoName (e-PCR)
- UniSTS:234894

UniSTS:234896 (e-PCR)
- UniSTS:234896

RH126724 (e-PCR)
- UniSTS:207609

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 292

Names: zinc finger protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429838.1 → NP_001416767.1 zinc finger protein 292 isoform 2

Status: VALIDATED

Source sequence(s)

BX465850, BX649603
NM_013889.3 → NP_038917.2 zinc finger protein 292 isoform 1

See identical proteins and their annotated locations for NP_038917.2

Status: VALIDATED

Source sequence(s)

BX465850, BX649603

Consensus CDS

CCDS51138.1

UniProtKB/Swiss-Prot

B1B0E1, B1B0E2, Q8BQX3, Q8BS87, Q8CGI6, Q922D3, Q9Z2U2

Related

ENSMUSP00000037233.6, ENSMUST00000047950.6

Conserved Domains (3) summary

COG5189
Location:1758 → 1944

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:724 → 744

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:542 → 561

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

34803110..34882982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164179.1 → XP_036020072.1 zinc finger protein 292 isoform X1

Conserved Domains (3) summary

COG5189
Location:1736 → 1922

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:702 → 722

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:520 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036164180.1 → XP_036020073.1 zinc finger protein 292 isoform X1

Conserved Domains (3) summary

COG5189
Location:1736 → 1922

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:702 → 722

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:520 → 539

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036164181.1 → XP_036020074.1 zinc finger protein 292 isoform X2

UniProtKB/TrEMBL

Q8CHF2

Conserved Domains (1) summary

sd00017
Location:734 → 757

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_006537978.5 → XP_006538041.1 zinc finger protein 292 isoform X3

Conserved Domains (3) summary

COG5048
Location:567 → 743

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:724 → 744

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:542 → 561

ZF_C2H2; C2H2 Zn finger [structural motif]