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    Nell1 neural EGFL like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81733, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nell1provided by RGD
    Official Full Name
    neural EGFL like 1provided by RGD
    Primary source
    RGD:620998
    See related
    EnsemblRapid:ENSRNOG00000015675 AllianceGenome:RGD:620998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables heparin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in positive regulation of apoptotic process; positive regulation of ossification; and regulation of osteoblast differentiation. Located in extracellular space. Used to study craniosynostosis. Orthologous to human NELL1 (neural EGFL like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 158.3), Lung (RPKM 60.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nell1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (108845462..109709858)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (99709305..100573872)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (105348577..106218970)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 53 Neighboring gene solute carrier family 6 member 5 Neighboring gene uncharacterized LOC120097222 Neighboring gene 60S ribosomal protein L31-like Neighboring gene RIKEN cDNA 4933405O20 gene like Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 7 Neighboring gene transfer RNA alanine (anticodon AGC) 61 Neighboring gene ferritin light chain 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NELL-1 injection maintains long-bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model. Kwak J, et al. Tissue Eng Part A, 2013 Feb. PMID 23083222, Free PMC Article
    2. Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model. Li W, et al. Plast Reconstr Surg, 2011 Feb. PMID 21285762, Free PMC Article
    3. An ectopic study of tissue-engineered bone with Nell-1 gene modified rat bone marrow stromal cells in nude mice. Hu JZ, et al. Chin Med J (Engl), 2009 Apr 20. PMID 19493425
    4. Nell-1 induced bone formation within the distracted intermaxillary suture. Cowan CM, et al. Bone, 2006 Jan. PMID 16243593
    5. Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. Zhang X, et al. J Bone Miner Res, 2003 Dec. PMID 14672347

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression levels of neural markers were increased in rat pulp and in cultured human dental pulp stem cells stimulated with Nell-1 protein. This is the first study to demonstrate the effect of Nell-1 on dental pulp cells neural-like differentiation.
      Title: Nell-1 promotes the neural-like differentiation of dental pulp cells.
    2. These findings suggested that combined use of NELL-1 and BMP2 could positively regulate pulp repair.
      Title: Effects of Nel-like molecule-1 and bone morphogenetic protein 2 combination on rat pulp repair.
    3. establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis
      Title: Novel Wnt Regulator NEL-Like Molecule-1 Antagonizes Adipogenesis and Augments Osteogenesis Induced by Bone Morphogenetic Protein 2.
    4. NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration.
      Title: Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1.
    5. Thus, NELL-1 effectively enhances in situ osteogenesis in the bone marrow, making it potentially useful in the prevention and treatment of osteoporotic fractures.
      Title: NELL-1 injection maintains long-bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model.
    6. Nell-1 can significantly improve bone regeneration in a femoral segmental defect in a dose-dependent manner and is a potent osteospecific growth factor.
      Title: Nell-1 enhances bone regeneration in a rat critical-sized femoral segmental defect model.
    7. Data show that Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure
      Title: Craniosynostosis in transgenic mice overexpressing Nell-1.
    8. Nell1 accelerates chondrocyte hypertrophy and endochondral bone formation.
      Title: Nell-1 induced bone formation within the distracted intermaxillary suture.
    9. Nell-1 overexpression disrupts these pathways resulting in craniofacial anomalies such as premature suture closure.
      Title: Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of osteoblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of ossification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of osteoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase C-binding protein NELL1
    Names
    NEL-like 1
    NEL-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031069.3 → NP_112331.2  protein kinase C-binding protein NELL1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      A6JBG8, D4A284, Q62919
      Related
      ENSRNOP00000112278.1, ENSRNOT00000145487.1
      Conserved Domains (6) summary
      smart00179
      Location:549 → 586
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:29 → 213
      TSPN; Thrombospondin N-terminal -like domains
      pfam07645
      Location:596 → 627
      EGF_CA; Calcium-binding EGF domain
      cl17735
      Location:273 → 331
      VWC; von Willebrand factor type C domain
      pfam12947
      Location:480 → 515
      EGF_3; EGF domain
      NF033759
      Location:386 → 556
      exchanger_TraA; outer membrane exchange protein TraA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      108845462..109709858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275221.1 → XP_063131291.1  protein kinase C-binding protein NELL1 isoform X3

    2. XM_063275215.1 → XP_063131285.1  protein kinase C-binding protein NELL1 isoform X2

    3. XM_017589771.3 → XP_017445260.1  protein kinase C-binding protein NELL1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A059
      Related
      ENSRNOP00000083529.1, ENSRNOT00000094328.2

    4. XM_039092192.2 → XP_038948120.1  protein kinase C-binding protein NELL1 isoform X4

      UniProtKB/TrEMBL
      A6JBG9
      Conserved Domains (3) summary
      smart00179
      Location:434 → 466
      EGF_CA; Calcium-binding EGF-like domain
      smart00210
      Location:29 → 213
      TSPN; Thrombospondin N-terminal -like domains
      pfam00093
      Location:273 → 331
      VWC; von Willebrand factor type C domain

    5. XM_039092195.2 → XP_038948123.1  protein kinase C-binding protein NELL1 isoform X5

      UniProtKB/TrEMBL
      A6JBG9
      Conserved Domains (2) summary
      smart00210
      Location:29 → 213
      TSPN; Thrombospondin N-terminal -like domains
      pfam00093
      Location:273 → 331
      VWC; von Willebrand factor type C domain

    6. XM_039092200.2 → XP_038948128.1  protein kinase C-binding protein NELL1 isoform X6

      UniProtKB/TrEMBL
      A6JBG9
      Conserved Domains (2) summary
      smart00210
      Location:29 → 213
      TSPN; Thrombospondin N-terminal -like domains
      pfam00093
      Location:273 → 331
      VWC; von Willebrand factor type C domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62919.3 GenPept UniProtKB/Swiss-Prot:Q62919

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