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    Arhgef1 Rho guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60323, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgef1provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 1provided by RGD
    Primary source
    RGD:620951
    See related
    EnsemblRapid:ENSRNOG00000020130 AllianceGenome:RGD:620951
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lsc; Lbcl2
    Summary
    Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in microtubule depolymerization. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 62. Orthologous to human ARHGEF1 (Rho guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 296.9), Spleen (RPKM 246.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgef1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89626884..89648823)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80499026..80520954)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81769212..81797237)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 Neighboring gene CD79a molecule Neighboring gene ETS repressor factor like Neighboring gene uncharacterized LOC134485104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endothelin-1 up-regulates p115RhoGEF in embryonic rat cardiomyocytes during the hypertrophic response. Porchia F, et al. J Recept Signal Transduct Res, 2008. PMID 18569527
    2. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. Eisenhaure TM, et al. J Biol Chem, 2003 Aug 15. PMID 12773540
    3. ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1. MacKay CE, et al. Free Radic Biol Med, 2017 Sep. PMID 28673614, Free PMC Article
    4. A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. Dubash AD, et al. J Cell Sci, 2007 Nov 15. PMID 17971419
    5. Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. Varma H, et al. J Biol Chem, 2010 Nov 26. PMID 20858895, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reactive oxygen species and SrcFK activate RhoA via ARHGEF1 in pulmonary artery.
      Title: ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1.
    2. results indicate that ROCK and its downstream target molecules, which are involved in inducing the hypertrophic response, are also implicated in signaling the up-regulation of the p115RhoGEF protein.
      Title: Endothelin-1 up-regulates p115RhoGEF in embryonic rat cardiomyocytes during the hypertrophic response.
    3. These data establish a previously uncharacterized role for the exchange factors Lsc/p115 RhoGEF and LARG in linking fibronectin signals to downstream RhoA activation.
      Title: A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108950

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 1
    Names
    Lymphoid blast crisis-like 2
    Rho guanine nucleotide exchange factor (GEF) 1
    lbc's second cousin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021694.3 → NP_067726.3  rho guanine nucleotide exchange factor 1

      See identical proteins and their annotated locations for NP_067726.3

      Status: PROVISIONAL

      Source sequence(s)
      BC091218
      UniProtKB/Swiss-Prot
      Q9Z1I6
      UniProtKB/TrEMBL
      Q5BK37
      Related
      ENSRNOP00000072904.2, ENSRNOT00000080840.3
      Conserved Domains (4) summary
      pfam05887
      Location:303 → 409
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cd08755
      Location:50 → 242
      RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
      smart00325
      Location:418 → 602
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd14679
      Location:636 → 760
      PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      89626884..89648823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088933.2 → XP_038944861.1  rho guanine nucleotide exchange factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JU01, E9PTJ8
      Related
      ENSRNOP00000068908.2, ENSRNOT00000080143.3
      Conserved Domains (4) summary
      cd08755
      Location:50 → 242
      RGS_p115RhoGEF; Regulator of G protein signaling (RGS) domain found in the Rho guanine nucleotide exchange factor (GEF), p115 RhoGEF
      smart00325
      Location:474 → 658
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      PRK14086
      Location:275 → 451
      dnaA; chromosomal replication initiator protein DnaA
      cd14679
      Location:692 → 816
      PH_p115RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

    2. XM_063272369.1 → XP_063128439.1  rho guanine nucleotide exchange factor 1 isoform X5

    3. XM_063272371.1 → XP_063128441.1  rho guanine nucleotide exchange factor 1 isoform X6

    4. XM_063272361.1 → XP_063128431.1  rho guanine nucleotide exchange factor 1 isoform X2

    5. XM_063272365.1 → XP_063128435.1  rho guanine nucleotide exchange factor 1 isoform X4

    6. XM_063272358.1 → XP_063128428.1  rho guanine nucleotide exchange factor 1 isoform X1

    7. XM_063272364.1 → XP_063128434.1  rho guanine nucleotide exchange factor 1 isoform X3

      UniProtKB/TrEMBL
      Q5BK37
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1I6.1 GenPept UniProtKB/Swiss-Prot:Q9Z1I6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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