Lcp2 lymphocyte cytosolic protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lcp2provided by RGD
Official Full Name: lymphocyte cytosolic protein 2provided by RGD
Primary source: RGD:619743
See related: EnsemblRapid:ENSRNOG00000005620 AllianceGenome:RGD:619743
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Slp76
Summary: Predicted to be involved in cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of protein kinase activity. Predicted to act upstream of or within mast cell activation. Predicted to be located in cell-cell junction; cytosol; and plasma membrane raft. Predicted to be part of TCR signalosome. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 212.4), Spleen (RPKM 146.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (19146846..19193750)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (18642600..18689562)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (18996523..19043289)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLCgamma1 can be primed for ITK-mediated phosphorylation on Y783 by a specific region of the adaptor protein, SLP-76.
Title: Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TCR signalosome	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lymphocyte cytosolic protein 2

Names: lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130421.2 → NP_569105.1 lymphocyte cytosolic protein 2

See identical proteins and their annotated locations for NP_569105.1

Status: PROVISIONAL

Source sequence(s)

BC100066

UniProtKB/TrEMBL

A0A8J8YIH6, F1LNJ9, Q920L0

Related

ENSRNOP00000098753.1, ENSRNOT00000168848.1

Conserved Domains (3) summary

cd09522
Location:10 → 78

SAM_SLP76; SAM domain of SLP76 subfamily

smart00454
Location:12 → 70

SAM; Sterile alpha motif

cd09929
Location:402 → 523

SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)