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    Naca nascent polypeptide associated complex subunit alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288770, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nacaprovided by RGD
    Official Full Name
    nascent polypeptide associated complex subunit alphaprovided by RGD
    Primary source
    RGD:1308642
    See related
    EnsemblRapid:ENSRNOG00000002632 AllianceGenome:RGD:1308642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable TBP-class protein binding activity; transcription coactivator activity; and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of protein localization to endoplasmic reticulum; positive regulation of skeletal muscle tissue growth; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within myoblast migration. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Orthologous to human NACA (nascent polypeptide associated complex subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 363.8), Spleen (RPKM 353.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naca in Genome Data Viewer
    Location:
    7q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1053474..1066606)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (468862..481992)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2458283..2470674)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene 17-beta-hydroxysteroid dehydrogenase type 6-like Neighboring gene transfer RNA proline (anticodon GGG) Neighboring gene DNA primase subunit 1 Neighboring gene prostaglandin E synthase 3 Neighboring gene uncharacterized LOC120093524 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity. Berkholz J, et al. Biochem J, 2013 Jul 15. PMID 23662692
    2. The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Yotov WV, et al. Mol Cell Biol, 1998 Mar. PMID 9488445, Free PMC Article
    3. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Park CY, et al. Proc Natl Acad Sci U S A, 2010 Nov 30. PMID 21071677, Free PMC Article
    4. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
    5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac ventricle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart trabecula morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myoblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of striated muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell proliferation involved in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of skeletal muscle tissue growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nascent polypeptide-associated complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nascent polypeptide-associated complex subunit alpha
    Names
    nascent polypeptide-associated complex alpha subunit
    nascent-polypeptide-associated complex alpha polypeptide
    NP_001099409.1
    NP_001185491.1
    NP_001185509.1
    XP_038934468.1
    XP_038934469.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105939.2 → NP_001099409.1  nascent polypeptide-associated complex subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_001099409.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2KAT8, B2RYX0
      Related
      ENSRNOP00000075523.3, ENSRNOT00000085092.3
      Conserved Domains (2) summary
      cd14415
      Location:169 → 214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84 → 131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    2. NM_001198562.2 → NP_001185491.1  nascent polypeptide-associated complex subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_001185491.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2KAT8, B2RYX0
      Related
      ENSRNOP00000003550.6, ENSRNOT00000003550.9
      Conserved Domains (2) summary
      cd14415
      Location:169 → 214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:84 → 131
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    3. NM_001198580.1 → NP_001185509.1  nascent polypeptide-associated complex subunit alpha isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional large exon in the CDS compared to variant 1. The resulting isoform (2) has a larger internal segment compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      M0R9L0
      Related
      ENSRNOP00000099310.1, ENSRNOT00000125870.1
      Conserved Domains (3) summary
      PHA03247
      Location:1075 → 1517
      PHA03247; large tegument protein UL36; Provisional
      cd14415
      Location:2117 → 2162
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:2032 → 2079
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1053474..1066606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078540.2 → XP_038934468.1  nascent polypeptide-associated complex subunit alpha isoform X1

      UniProtKB/TrEMBL
      M0R9L0
      Related
      ENSRNOP00000066181.1, ENSRNOT00000075681.5
      Conserved Domains (3) summary
      PHA03247
      Location:1075 → 1517
      PHA03247; large tegument protein UL36; Provisional
      cd14415
      Location:2117 → 2162
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:2032 → 2079
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit

    2. XM_039078541.2 → XP_038934469.1  nascent polypeptide-associated complex subunit alpha isoform X1

      UniProtKB/TrEMBL
      M0R9L0
      Conserved Domains (3) summary
      PHA03247
      Location:1075 → 1517
      PHA03247; large tegument protein UL36; Provisional
      cd14415
      Location:2117 → 2162
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      cd22054
      Location:2032 → 2079
      NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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