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    Atf7ip activating transcription factor 7 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312800, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Atf7ipprovided by RGD
    Official Full Name
    activating transcription factor 7 interacting proteinprovided by RGD
    Primary source
    RGD:1306030
    See related
    EnsemblRapid:ENSRNOG00000008870 AllianceGenome:RGD:1306030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity and transcription corepressor activity. Predicted to be involved in several processes, including positive regulation of DNA methylation-dependent heterochromatin assembly; protein stabilization; and regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human ATF7IP (activating transcription factor 7 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 244.0), Spleen (RPKM 208.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atf7ip in Genome Data Viewer
    Location:
    4q43
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (171117122..171202871)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (169385872..169471652)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (170476998..170563063)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486855 Neighboring gene uncharacterized LOC120102185 Neighboring gene uncharacterized LOC102549638 Neighboring gene phospholipase B domain containing 1 Neighboring gene guanylate cyclase 2C Neighboring gene uncharacterized LOC134486648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MCAF mediates MBD1-dependent transcriptional repression. Fujita N, et al. Mol Cell Biol, 2003 Apr. PMID 12665582, Free PMC Article
    2. ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex. Timms RT, et al. Cell Rep, 2016 Oct 11. PMID 27732843, Free PMC Article
    3. A murine ATFa-associated factor with transcriptional repressing activity. De Graeve F, et al. Oncogene, 2000 Mar 30. PMID 10777215
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    activating transcription factor 7-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107893.3 → NP_001101363.2  activating transcription factor 7-interacting protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5ZNS2
      Related
      ENSRNOP00000107375.1, ENSRNOT00000146270.1
      Conserved Domains (4) summary
      PTZ00121
      Location:410 → 705
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:694 → 1213
      PHA03247; large tegument protein UL36; Provisional
      pfam16788
      Location:604 → 815
      ATF7IP_BD; ATF-interacting protein binding domain
      pfam16794
      Location:1199 → 1299
      fn3_4; Fibronectin-III type domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      171117122..171202871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286153.1 → XP_063142223.1  activating transcription factor 7-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      D3ZS88
      Related
      ENSRNOP00000079952.2, ENSRNOT00000113634.2

    2. XM_063286156.1 → XP_063142226.1  activating transcription factor 7-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      D3ZS88

    3. XM_063286157.1 → XP_063142227.1  activating transcription factor 7-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      D3ZS88

    4. XM_063286154.1 → XP_063142224.1  activating transcription factor 7-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      D3ZS88
      Related
      ENSRNOP00000110923.1, ENSRNOT00000164196.1

    5. XM_063286155.1 → XP_063142225.1  activating transcription factor 7-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNS2
    Nucleotide Protein Strain
    Heading Accession and Version

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