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    Shisa7 shisa family member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691429, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Shisa7provided by RGD
    Official Full Name
    shisa family member 7provided by RGD
    Primary source
    RGD:1583944
    See related
    EnsemblRapid:ENSRNOG00000016877 AllianceGenome:RGD:1583944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GABA receptor binding activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Predicted to be located in asymmetric, glutamatergic, excitatory synapse. Predicted to be active in glutamatergic synapse; postsynaptic density; and synaptic membrane. Orthologous to human SHISA7 (shisa family member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 25.3), Testes (RPKM 6.3) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Shisa7 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78022680..78041748)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (68993900..69012943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72545413..72564513)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit C, pseudogene 2 Neighboring gene isochorismatase domain containing 2b Neighboring gene uncharacterized LOC134482885 Neighboring gene ubiquitin-conjugating enzyme E2S

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Shisa7 is a GABA(A) receptor auxiliary subunit controlling benzodiazepine actions. Han W, et al. Science, 2019 Oct 11. PMID 31601770, Free PMC Article
    2. The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory. Schmitz LJM, et al. Elife, 2017 Dec 4. PMID 29199957, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of AMPA glutamate receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of AMPA receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of GABA-A receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    NOT part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in asymmetric, glutamatergic, excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in asymmetric, glutamatergic, excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendritic spine membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein shisa-7
    Names
    shisa homolog 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145175.1 → NP_001138647.1  protein shisa-7 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZPJ0
      Related
      ENSRNOP00000022698.3, ENSRNOT00000022698.5
      Conserved Domains (1) summary
      pfam13908
      Location:83 → 142
      Shisa; Wnt and FGF inhibitory regulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      78022680..78041748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274859.1 → XP_063130929.1  protein shisa-7 isoform X2

      Related
      ENSRNOP00000108986.1, ENSRNOT00000161994.1

    2. XM_017589753.3 → XP_017445242.1  protein shisa-7 isoform X1

      UniProtKB/TrEMBL
      D3ZPJ0
      Conserved Domains (1) summary
      pfam13908
      Location:83 → 142
      Shisa; Wnt and FGF inhibitory regulator

    3. XM_039091565.2 → XP_038947493.1  protein shisa-7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ANL3
      Related
      ENSRNOP00000094674.1, ENSRNOT00000114646.2
      Conserved Domains (1) summary
      pfam13908
      Location:83 → 142
      Shisa; Wnt and FGF inhibitory regulator

    4. XM_039091559.2 → XP_038947487.1  protein shisa-7 isoform X1

      UniProtKB/TrEMBL
      D3ZPJ0
      Conserved Domains (1) summary
      pfam13908
      Location:83 → 142
      Shisa; Wnt and FGF inhibitory regulator

    5. XM_017589754.3 → XP_017445243.1  protein shisa-7 isoform X1

      UniProtKB/TrEMBL
      D3ZPJ0
      Conserved Domains (1) summary
      pfam13908
      Location:83 → 142
      Shisa; Wnt and FGF inhibitory regulator

    6. XM_017589755.3 → XP_017445244.1  protein shisa-7 isoform X1

      UniProtKB/TrEMBL
      D3ZPJ0
      Conserved Domains (1) summary
      pfam13908
      Location:83 → 142
      Shisa; Wnt and FGF inhibitory regulator

    7. XM_063274863.1 → XP_063130933.1  protein shisa-7 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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