Art4 ADP-ribosyltransferase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Art4provided by RGD
Official Full Name: ADP-ribosyltransferase 4provided by RGD
Primary source: RGD:1306456
See related: Ensembl:ENSRNOG00000005670 AllianceGenome:RGD:1306456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ATR4
Summary: Predicted to enable NAD+ ADP-ribosyltransferase activity. Predicted to be involved in peptidyl-arginine ADP-ribosylation. Orthologous to human ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 130.5), Thymus (RPKM 130.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q43

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (171468415..171482435, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (169740331..169751571, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (170830851..170841187, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein-arginine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ecto-ADP-ribosyltransferase 4

Names: ADP-ribosyltransferase 4 (Dombrock blood group); NAD(P)(+)--arginine ADP-ribosyltransferase

NP_001166980.1

EC 2.4.2.31

XP_038963627.1

EC 2.4.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173509.1 → NP_001166980.1 ecto-ADP-ribosyltransferase 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IMI9, F1MA10

Related

ENSRNOP00000007485.4, ENSRNOT00000007485.6

Conserved Domains (1) summary

cl00173
Location:41 → 261

VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

171468415..171482435 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107699.2 → XP_038963627.1 ecto-ADP-ribosyltransferase 4 isoform X1

UniProtKB/TrEMBL

A6IMI9

Conserved Domains (1) summary

cl00173
Location:37 → 257

VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...