Kmt5c lysine methyltransferase 5C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kmt5cprovided by RGD
Official Full Name: lysine methyltransferase 5Cprovided by RGD
Primary source: RGD:1305226
See related: EnsemblRapid:ENSRNOG00000017508 AllianceGenome:RGD:1305226
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Suv420h2
Summary: Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; histone binding activity; and histone methyltransferase activity (H4-K20 specific). Predicted to be involved in DNA repair; histone H4-K20 trimethylation; and positive regulation of DNA metabolic process. Predicted to act upstream of or within histone methylation. Predicted to be located in condensed chromosome, centromeric region; nucleoplasm; and pericentric heterochromatin. Predicted to be active in nucleus. Biomarker of liver benign neoplasm. Orthologous to human KMT5C (lysine methyltransferase 5C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 32.9), Adrenal (RPKM 30.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78128325..78135931, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69099531..69107145, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72666662..72674271, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suv4-20h2 and Suv-39h1 histone methyltransferases are expressed and Histone H3 lysine 9 and H4 lysine 20 are trimethylated in hepatocarcinogenesis induced by methyl deficiency in rats [Suv4-20h2 and Suv-39h1]
Title: Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.

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General gene information

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Markers

BE107946 (e-PCR)
- UniSTS:247125

BF396701 (e-PCR)
- UniSTS:245851

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K20 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K20 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4K20 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H4K20 monomethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20me methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of isotype switching	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of isotype switching	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
part_of heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of pericentric heterochromatin	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase KMT5C

Names: [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H2; lysine (K)-specific methyltransferase 5C; lysine-specific methyltransferase 5C; su(var)4-20 homolog 2; suppressor of variegation 4-20 homolog 2; suv4-20h2

NP_001100945.1

EC 2.1.1.361

EC 2.1.1.362

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.