Prl3b1 prolactin family 3, subfamily B, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prl3b1provided by RGD
Official Full Name: prolactin family 3, subfamily B, member 1provided by RGD
Primary source: RGD:2429
See related: EnsemblRapid:ENSRNOG00000017185 AllianceGenome:RGD:2429
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pl2; Csh2; Ghd15; PL-II; RPLII
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 17p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (37952063..37957722, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (37743681..37749340, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (42771523..42777186, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circadian changes in placental lactogen-2 gene expression in the placenta.
Title: Circadian expression of Mel1a and PL-II genes in placenta: effects of melatonin on the PL-II gene expression in the rat placenta.
data support a role for AP2 gamma in the placental giant cell-specific expression of the placental lactogen II gene
Title: Proteomic identification of AP2 gamma as a rat placental lactogen II trophoblast cell-specific enhancer binding protein.

Submit: New GeneRIF Correction

General gene information

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Markers

D17Wox24 (e-PCR)
- UniSTS:239507

RH94718 (e-PCR)
- UniSTS:119965

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prolactin-3B1

Names: Placental lactogen-2; chorionic somatomammotropin hormone 2; growth hormone d15; placental lactogen 2; placental lactogen II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012535.3 → NP_036667.1 prolactin-3B1 precursor

See identical proteins and their annotated locations for NP_036667.1

Status: VALIDATED

Source sequence(s)

BC097255

UniProtKB/Swiss-Prot

O70245, P09321, Q4QRC3

UniProtKB/TrEMBL

A0A0M5HDY9, A6J7S9

Related

ENSRNOP00000023086.3, ENSRNOT00000023086.7

Conserved Domains (1) summary

cd10288
Location:24 → 221

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones