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    Akap13 A-kinase anchoring protein 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293024, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Akap13provided by RGD
    Official Full Name
    A-kinase anchoring protein 13provided by RGD
    Primary source
    RGD:727893
    See related
    EnsemblRapid:ENSRNOG00000010964 AllianceGenome:RGD:727893
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AKAP-13; AKAP-Lbc
    Summary
    Enables MAP-kinase scaffold activity. Involved in several processes, including adrenergic receptor signaling pathway; cell growth involved in cardiac muscle cell development; and positive regulation of intracellular signal transduction. Located in perinuclear region of cytoplasm. Orthologous to human AKAP13 (A-kinase anchoring protein 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 290.1), Spleen (RPKM 232.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akap13 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (138722445..139029401)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (129313183..129619647)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (137089558..137315272)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL13-like Neighboring gene synaptic vesicle glycoprotein 2b Neighboring gene uncharacterized LOC134485139 Neighboring gene uncharacterized LOC134485140 Neighboring gene family with sequence similarity 24, member A like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblasts. Cavin S, et al. Biochim Biophys Acta, 2014 Feb. PMID 24269843
    2. Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis. Koide H, et al. J Bone Miner Res, 2015 Oct. PMID 25892096, Free PMC Article
    3. AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy. Spindler MJ, et al. PLoS One, 2013. PMID 23658642, Free PMC Article
    4. In vitro reconstitution of an erythropoietin gene transcription system using its 5'-flanking sequence and a nuclear extract from anemic kidney. Tsuchiya T, et al. Biochem Biophys Res Commun, 1992 Jan 15. PMID 1731775
    5. The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex. Abdul Azeez KR, et al. Biochem J, 2014 Dec 1. PMID 25186459, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP-kinase scaffold activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP-kinase scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adrenergic receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adrenergic receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell growth involved in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of glucocorticoid mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of sarcomere organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A-kinase anchor protein 13
    Names
    A kinase (PRKA) anchor protein 13
    protein kinase A anchoring protein Rt31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106271.3 → NP_001099741.2  A-kinase anchor protein 13

      See identical proteins and their annotated locations for NP_001099741.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      F1M3G7, Q8VHU6
      UniProtKB/TrEMBL
      A0A8I6GDR4
      Related
      ENSRNOP00000086170.1, ENSRNOT00000103755.2
      Conserved Domains (5) summary
      smart00109
      Location:1754 → 1800
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      cd00160
      Location:1957 → 2151
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam00169
      Location:2227 → 2279
      PH; PH domain
      pfam06476
      Location:2560 → 2617
      DUF1090; Protein of unknown function (DUF1090)
      cl17171
      Location:2194 → 2281
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      138722445..139029401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105531.2 → XP_038961459.1  A-kinase anchor protein 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y2J4, A0A8L2Q7A1
      Related
      ENSRNOP00000014802.7, ENSRNOT00000014802.8
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1975 → 2169
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2509 → 2669
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2212 → 2314
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1769 → 1824
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    2. XM_039105543.2 → XP_038961471.1  A-kinase anchor protein 13 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1975 → 2169
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2508 → 2668
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2212 → 2314
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1769 → 1824
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    3. XM_039105541.2 → XP_038961469.1  A-kinase anchor protein 13 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1974 → 2168
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2508 → 2668
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2211 → 2313
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1769 → 1824
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    4. XM_063284528.1 → XP_063140598.1  A-kinase anchor protein 13 isoform X6

    5. XM_039105548.2 → XP_038961476.1  A-kinase anchor protein 13 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1973 → 2167
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2507 → 2667
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2210 → 2312
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1769 → 1824
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    6. XM_039105547.2 → XP_038961475.1  A-kinase anchor protein 13 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1974 → 2168
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2508 → 2668
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2211 → 2313
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1769 → 1824
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    7. XM_063284529.1 → XP_063140599.1  A-kinase anchor protein 13 isoform X7

    8. XM_039105554.2 → XP_038961482.1  A-kinase anchor protein 13 isoform X9

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Related
      ENSRNOP00000078206.1, ENSRNOT00000095963.2
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1953 → 2147
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2487 → 2647
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2190 → 2292
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1747 → 1802
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    9. XM_039105549.2 → XP_038961477.1  A-kinase anchor protein 13 isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y2J4, A0A8I6AJL6
      Related
      ENSRNOP00000088819.1, ENSRNOT00000101691.2
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1957 → 2151
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2491 → 2651
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2194 → 2296
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1751 → 1806
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    10. XM_039105560.2 → XP_038961488.1  A-kinase anchor protein 13 isoform X10

      UniProtKB/TrEMBL
      A0A8I5XVJ8, A0A8I5Y2J4
      Related
      ENSRNOP00000076907.1, ENSRNOT00000108771.2
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1935 → 2129
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2469 → 2629
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2172 → 2274
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1729 → 1784
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    11. XM_039105567.2 → XP_038961495.1  A-kinase anchor protein 13 isoform X11

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1933 → 2127
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2467 → 2627
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2170 → 2272
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1729 → 1784
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    12. XM_039105573.2 → XP_038961501.1  A-kinase anchor protein 13 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y2J4, A0A8L2Q7A1
      Related
      ENSRNOP00000105310.1, ENSRNOT00000132269.1
      Conserved Domains (5) summary
      PHA03307
      Location:545 → 837
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1975 → 2169
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2509 → 2669
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2212 → 2314
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1769 → 1824
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    13. XM_039105585.2 → XP_038961513.1  A-kinase anchor protein 13 isoform X13

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Conserved Domains (5) summary
      PHA03307
      Location:268 → 560
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1698 → 1892
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2232 → 2392
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:1935 → 2037
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1492 → 1547
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    14. XM_039105578.2 → XP_038961506.1  A-kinase anchor protein 13 isoform X12

      UniProtKB/TrEMBL
      A0A8I5Y2J4
      Conserved Domains (5) summary
      PHA03307
      Location:337 → 629
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00160
      Location:1767 → 1961
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02168
      Location:2301 → 2461
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd13392
      Location:2004 → 2106
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      cd20878
      Location:1561 → 1616
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    15. XM_039105587.2 → XP_038961515.1  A-kinase anchor protein 13 isoform X14

      Conserved Domains (4) summary
      cd00160
      Location:669 → 863
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13392
      Location:906 → 1008
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      pfam17380
      Location:1216 → 1359
      DUF5401; Family of unknown function (DUF5401)
      cd20878
      Location:463 → 518
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    16. XM_063284555.1 → XP_063140625.1  A-kinase anchor protein 13 isoform X17

    17. XM_063284552.1 → XP_063140622.1  A-kinase anchor protein 13 isoform X16

    18. XM_063284561.1 → XP_063140631.1  A-kinase anchor protein 13 isoform X20

    19. XM_039105588.2 → XP_038961516.1  A-kinase anchor protein 13 isoform X15

      Conserved Domains (4) summary
      cd00160
      Location:654 → 848
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13392
      Location:891 → 993
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      pfam17380
      Location:1201 → 1344
      DUF5401; Family of unknown function (DUF5401)
      cd20878
      Location:448 → 503
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    20. XM_039105591.2 → XP_038961519.1  A-kinase anchor protein 13 isoform X19

      Conserved Domains (4) summary
      cd00160
      Location:613 → 807
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13392
      Location:850 → 952
      PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain
      pfam17380
      Location:1160 → 1303
      DUF5401; Family of unknown function (DUF5401)
      cd20878
      Location:408 → 463
      C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

    21. XM_063284557.1 → XP_063140627.1  A-kinase anchor protein 13 isoform X18

    22. XM_063284569.1 → XP_063140639.1  A-kinase anchor protein 13 isoform X21

    23. XM_063284572.1 → XP_063140642.1  A-kinase anchor protein 13 isoform X22

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1M3G7.2 GenPept UniProtKB/Swiss-Prot:F1M3G7

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