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    Aen apoptosis enhancing nuclease [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361594, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Aenprovided by RGD
    Official Full Name
    apoptosis enhancing nucleaseprovided by RGD
    Primary source
    RGD:1305051
    See related
    EnsemblRapid:ENSRNOG00000018421 AllianceGenome:RGD:1305051
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Isg20l1; RGD1305051
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human AEN (apoptosis enhancing nuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 75.3), Spleen (RPKM 69.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aen in Genome Data Viewer
    Location:
    1q31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (142224499..142233902)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (132815094..132824522)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (140584328..140593749)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099862 Neighboring gene uncharacterized LOC120099863 Neighboring gene microRNA 8 Neighboring gene interferon stimulated exonuclease gene 20 Neighboring gene uncharacterized LOC102547609

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis. Lee JH, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16171785
    2. p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis. Kawase T, et al. Oncogene, 2008 Jun 19. PMID 18264133
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-enhancing nuclease
    Names
    interferon stimulated exonuclease gene 20-like 1
    interferon-stimulated 20 kDa exonuclease-like 1
    NP_001101957.1
    XP_006229461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108487.2 → NP_001101957.1  apoptosis-enhancing nuclease

      See identical proteins and their annotated locations for NP_001101957.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166435
      UniProtKB/Swiss-Prot
      B2GUW6
      Related
      ENSRNOP00000062841.1, ENSRNOT00000064438.3
      Conserved Domains (2) summary
      COG0847
      Location:102 → 263
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl10012
      Location:106 → 262
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      142224499..142233902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229399.5 → XP_006229461.1  apoptosis-enhancing nuclease isoform X1

      See identical proteins and their annotated locations for XP_006229461.1

      UniProtKB/Swiss-Prot
      B2GUW6
      Conserved Domains (2) summary
      COG0847
      Location:102 → 263
      DnaQ; DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]
      cl10012
      Location:106 → 262
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GUW6.1 GenPept UniProtKB/Swiss-Prot:B2GUW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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