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    Ggta1 glycoprotein alpha-galactosyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246766, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Ggta1provided by RGD
    Official Full Name
    glycoprotein alpha-galactosyltransferase 1provided by RGD
    Primary source
    RGD:629476
    See related
    EnsemblRapid:ENSRNOG00000019179 AllianceGenome:RGD:629476
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ggta1p
    Summary
    Predicted to enable glycosyltransferase activity. Involved in protein galactosylation at cell surface. Located in Golgi cisterna. Orthologous to human GGTA1 (glycoprotein alpha-galactosyltransferase 1 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 234.3), Spleen (RPKM 179.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ggta1 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (39130466..39208652, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18732985..18824916, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14614099..14701185, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930402F06 gene like Neighboring gene spermidine synthase-like Neighboring gene uncharacterized LOC120101529 Neighboring gene uncharacterized LOC120101530 Neighboring gene uncharacterized LOC102549213 Neighboring gene uncharacterized LOC120101531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymes that synthesize the IB4 epitope are not sufficient to impart IB4 binding in dorsal root ganglia of rat. Fullmer JM, et al. J Comp Neurol, 2007 Mar 1. PMID 17206613
    2. Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways. Taylor SG, et al. Glycobiology, 2003 May. PMID 12626403
    3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyllactosaminide 3-alpha-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in lipid glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyllactosaminide alpha-1,3-galactosyltransferase
    Names
    UDP-galactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase
    galactosyltransferase
    glycoprotein galactosyltransferase alpha 1, 3
    glycoprotein, alpha-galactosyltransferase 1,3
    NP_663707.1
    XP_006234095.1
    XP_006234099.1
    XP_008759922.1
    XP_008759924.1
    XP_017446957.1
    XP_017446958.1
    XP_017446959.1
    XP_038960200.1
    XP_038960201.1
    XP_038960202.1
    XP_038960203.1
    XP_038960204.1
    XP_038960206.1
    XP_038960207.1
    XP_063139165.1
    XP_063139166.1
    XP_063139167.1
    XP_063139168.1
    XP_063139169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145674.1 → NP_663707.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase

      See identical proteins and their annotated locations for NP_663707.1

      Status: PROVISIONAL

      Source sequence(s)
      AF520589
      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      39130466..39208652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591470.3 → XP_017446959.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:27 → 310
      Glyco_transf_6; Glycosyltransferase family 6

    2. XM_008761702.4 → XP_008759924.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

      See identical proteins and their annotated locations for XP_008759924.1

      UniProtKB/TrEMBL
      A0A0H2UHR0, A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:52 → 335
      Glyco_transf_6; Glycosyltransferase family 6

    3. XM_006234033.5 → XP_006234095.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006234095.1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    4. XM_039104273.2 → XP_038960201.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    5. XM_008761700.4 → XP_008759922.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_008759922.1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    6. XM_063283097.1 → XP_063139167.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    7. XM_039104278.2 → XP_038960206.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHR0, A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:52 → 335
      Glyco_transf_6; Glycosyltransferase family 6

    8. XM_039104274.2 → XP_038960202.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Related
      ENSRNOP00000025983.5, ENSRNOT00000025983.6
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    9. XM_017591468.3 → XP_017446957.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    10. XM_063283099.1 → XP_063139169.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    11. XM_039104275.2 → XP_038960203.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    12. XM_063283098.1 → XP_063139168.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

    13. XM_063283096.1 → XP_063139166.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHR0

    14. XM_039104272.2 → XP_038960200.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    15. XM_063283095.1 → XP_063139165.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHR0

    16. XM_017591469.3 → XP_017446958.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    17. XM_039104276.2 → XP_038960204.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Related
      ENSRNOP00000083720.1, ENSRNOT00000107236.2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6

    18. XM_039104279.2 → XP_038960207.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:27 → 310
      Glyco_transf_6; Glycosyltransferase family 6

    19. XM_006234037.5 → XP_006234099.1  N-acetyllactosaminide alpha-1,3-galactosyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006234099.1

      UniProtKB/Swiss-Prot
      Q3L7M0, Q80WF5, Q8K3Z1
      UniProtKB/TrEMBL
      A0A8I6AAD2
      Conserved Domains (1) summary
      pfam03414
      Location:86 → 369
      Glyco_transf_6; Glycosyltransferase family 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3L7M0.2 GenPept UniProtKB/Swiss-Prot:Q3L7M0

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